SYP-5 is an inhibitor of hypoxia-inducible factor-1 (HIF-1). It inhibits HIF-1 activity in a reporter assay when used at concentrations ranging from 0.1 to 100 µM. SYP-5 (2, 10, and 50 µM) reduces hypoxia- or VEGF-induced capillary tube formation in human umbilical vein endothelial cells (HUVECs). It inhibits the migration and invasion of Hep3B hepatocellular carcinoma and BCaP-37 breast cancer cells in a concentration-dependent manner.
MedKoo Cat#: 465290
Name: SYP-5
CAS#: 1384268-04-5
Chemical Formula: C18H16O3S
Exact Mass: 312.0820
Molecular Weight: 312.38
Elemental Analysis: C, 69.21; H, 5.16; O, 15.36; S, 10.26
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 30.0 | 96.04 | |
| DMF:PBS (pH 7.2) (1:2) | 0.3 | 0.96 | |
| DMSO | 25.0 | 80.03 | |
| Ethanol | 1.0 | 3.20 |
The following data is based on the product molecular weight 312.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
