SPL-707 is the first selective and orally active SPPL2a inhibitor. It shows adequate selectivity against the closely related enzymes γ-secretase and SPP and a good pharmacokinetic profile in mouse and rat.
MedKoo Cat#: 561898
Name: SPL-707
CAS#: 2195361-33-0
Chemical Formula: C27H28FN5O4
Exact Mass: 505.2125
Molecular Weight: 505.55
Elemental Analysis: C, 64.15; H, 5.58; F, 3.76; N, 13.85; O, 12.66
The following data is based on the product molecular weight 505.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |