MedKoo Cat#: 531559 | Name: BMS753
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

BMS753 is a RARα-selective agonist (Ki = 2 nM). It regulates the ATRA-inducible cytochrome P450 26A1 (CYP26A1).

Chemical Structure

BMS753
CAS#215307-86-1

Theoretical Analysis

MedKoo Cat#: 531559

Name: BMS753

CAS#: 215307-86-1

Chemical Formula: C21H21NO4

Exact Mass: 351.1471

Molecular Weight: 351.40

Elemental Analysis: C, 71.78; H, 6.02; N, 3.99; O, 18.21

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 600.00 2 Weeks
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Related CAS #
No Data
Synonym
BMS753; BMS 753; BMS-753.
IUPAC/Chemical Name
4-[(1,1,3,3-tetramethyl-2-oxoindene-5-carbonyl)amino]benzoic acid
InChi Key
KFBPBWUZXBYJDG-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H21NO4/c1-20(2)15-10-7-13(11-16(15)21(3,4)19(20)26)17(23)22-14-8-5-12(6-9-14)18(24)25/h5-11H,1-4H3,(H,22,23)(H,24,25)
SMILES Code
O=C(O)C1=CC=C(NC(C2=CC3=C(C(C)(C)C(C3(C)C)=O)C=C2)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 351.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Idres N, Marill J, Chabot GG. Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells. Biochem Pharmacol. 2005 Jun 1;69(11):1595-601. PubMed PMID: 15896339.