Leucomyosuppressin | CAS#106884-19-9 | inibitor

MedKoo Cat#: 598666 | Name: Leucomyosuppressin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Leucomyosuppressin is isolated from head extracts of the cockroach Leucophaea maderae; inhibits evoked transmitter release at the mealworm neuromuscular junction.

Chemical Structure

Leucomyosuppressin

CAS#106884-19-9

Theoretical Analysis

MedKoo Cat#: 598666

Name: Leucomyosuppressin

CAS#: 106884-19-9

Chemical Formula: C59H84N16O15

Exact Mass: 1256.6302

Molecular Weight: 1257.41

Elemental Analysis: C, 56.36; H, 6.73; N, 17.82; O, 19.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Leucomyosuppressin; p-Glu-asp-val-asp-his-val-phe-leu-arg-phe-NH2;

IUPAC/Chemical Name

(6S,9R,12S,15S,18R,21S,24S,27S)-18-((1H-imidazol-5-yl)methyl)-1-amino-6-(((R)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-12-benzyl-21-(carboxymethyl)-1-imino-9-isobutyl-15,24-diisopropyl-8,11,14,17,20,23,26-heptaoxo-27-((S)-5-oxopyrrolidine-2-carboxamido)-2,7,10,13,16,19,22,25-octaazanonacosan-29-oic acid

InChi Key

RFZUUYLDHNDZQI-XOHVDFTBSA-N

InChi Code

1S/C59H84N16O15/c1-30(2)22-39(52(84)67-36(18-13-21-64-59(61)62)50(82)68-38(49(60)81)23-33-14-9-7-10-15-33)69-53(85)40(24-34-16-11-8-12-17-34)72-57(89)47(31(3)4)74-55(87)41(25-35-28-63-29-65-35)70-54(86)42(26-45(77)78)73-58(90)48(32(5)6)75-56(88)43(27-46(79)80)71-51(83)37-19-20-44(76)66-37/h7-12,14-17,28-32,36-43,47-48H,13,18-27H2,1-6H3,(H2,60,81)(H,63,65)(H,66,76)(H,67,84)(H,68,82)(H,69,85)(H,70,86)(H,71,83)(H,72,89)(H,73,90)(H,74,87)(H,75,88)(H,77,78)(H,79,80)(H4,61,62,64)/t36?,37-,38+,39+,40-,41?,42-,43-,47-,48-/m0/s1

SMILES Code

O=C([C@@H](NC([C@@H](NC([C@@H]1CCC(N1)=O)=O)CC(O)=O)=O)C(C)C)N[C@@H](CC(O)=O)C(N[C@@H](C(N[C@@H](C(C)C)C(N[C@@H](Cc2ccccc2)C(N[C@@H](C(N[C@H](C(N[C@@H](C(N)=O)Cc3ccccc3)=O)CCCNC(N)=N)=O)CC(C)C)=O)=O)=O)Cc4[nH]cnc4)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,257.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Maestro JL, Tobe SS, Belles X. Leucomyosuppressin modulates cardiac rhythm in the cockroach Blattella germanica. J Insect Physiol. 2011 Dec;57(12):1677-81. doi: 10.1016/j.jinsphys.2011.09.001. Epub 2011 Sep 8. PubMed PMID: 21925505. 2: Söhler S, Neupert S, Predel R, Nichols R, Stengl M. Localization of leucomyosuppressin in the brain and circadian clock of the cockroach Leucophaea maderae. Cell Tissue Res. 2007 May;328(2):443-52. Epub 2007 Jan 10. PubMed PMID: 17216199. 3: Vilaplana L, Castresana J, Bellés X. The cDNA for leucomyosuppressin in Blattella germanica and molecular evolution of insect myosuppressins. Peptides. 2004 Nov;25(11):1883-9. PubMed PMID: 15501519. 4: Bendena WG, Donly BC, Fuse M, Lee E, Lange AB, Orchard I, Tobe SS. Molecular characterization of the inhibitory myotropic peptide leucomyosuppressin. Peptides. 1997;18(1):157-63. Review. PubMed PMID: 9114465. 5: Aguilar R, Maestro JL, Vilaplana L, Chiva C, Andreu D, Bellés X. Identification of leucomyosuppressin in the German cockroach, Blattella germanica, as an inhibitor of food intake. Regul Pept. 2004 Jun 15;119(1-2):105-12. PubMed PMID: 15093704. 6: Donly BC, Fuse M, Orchard I, Tobe SS, Bendena WG. Characterization of the gene for leucomyosuppressin and its expression in the brain of the cockroach Diploptera punctata. Insect Biochem Mol Biol. 1996 Jun;26(6):627-37. PubMed PMID: 8969471. 7: Meola SM, Wright MS, Holman GM, Thompson JM. Immunocytochemical localization of leucomyosuppressin-like peptides in the CNS of the cockroach, Leucophaea maderae. Neurochem Res. 1991 May;16(5):543-9. PubMed PMID: 1754030. 8: Matthews HJ, Audsley N, Weaver RJ. Degradation of leucomyosuppressin by enzymes in the hemolymph and midgut of Lacanobia oleracea and Spodoptera littoralis (Lepidoptera: Noctuidae) larvae. Peptides. 2009 Mar;30(3):565-70. doi: 10.1016/j.peptides.2008.12.020. Epub 2008 Dec 30. PubMed PMID: 19154766. 9: Yamamoto D, Ishikawa S, Holman GM, Nachman RJ. Leucomyosuppressin, a novel insect neuropeptide, inhibits evoked transmitter release at the mealworm neuromuscular junction. Neurosci Lett. 1988 Dec 19;95(1-3):137-42. PubMed PMID: 2852317. 10: Meola SM, Wright MS, Holman GM, Thompson JM. Localization of leucomyosuppressin-like peptides in the central nervous system of the stable fly with immunocytochemistry. J Med Entomol. 1991 Sep;28(5):712-8. PubMed PMID: 1941941. 11: Cook BJ, Wagner RM. Comparative effects of leucomyosuppressin on the visceral muscle systems of the cockroach Leucophaea maderae. Comp Biochem Physiol C. 1991;99(1-2):95-9. PubMed PMID: 1675975. 12: Fusé M, Orchard I. The muscular contractions of the midgut of the cockroach, Diploptera punctata: effects of the insect neuropeptides proctolin and leucomyosuppressin. Regul Pept. 1998 Oct 16;77(1-3):163-8. PubMed PMID: 9809811. 13: Fusé M, Bendena WG, Donly BC, Tobe SS, Orchard I. In situ hybridization analysis of leucomyosuppressin mRNA expression in the cockroach, Diploptera punctata. J Comp Neurol. 1998 Jun 8;395(3):328-41. PubMed PMID: 9596527. 14: Audsley N, Weaver RJ. Analysis of peptides in the brain and corpora cardiaca-corpora allata of the honey bee, Apis mellifera using MALDI-TOF mass spectrometry. Peptides. 2006 Mar;27(3):512-20. Epub 2005 Nov 22. PubMed PMID: 16309791. 15: Fusé M, Zhang JR, Partridge E, Nachman RJ, Orchard I, Bendena WG, Tobe SS. Effects of an allatostatin and a myosuppressin on midgut carbohydrate enzyme activity in the cockroach Diploptera punctata. Peptides. 1999 Nov;20(11):1285-93. PubMed PMID: 10612442. 16: Meola SM, Wright MS, Nichols R, Pendleton MW. Localization of myosuppressinlike peptides in the hypocerebral ganglion of two blood-feeding flies: horn fly and stable fly (Diptera:Muscidae). J Med Entomol. 1996 May;33(3):473-81. PubMed PMID: 8667397. 17: Down RE, Matthews HJ, Audsley N. Oral activity of FMRFamide-related peptides on the pea aphid Acyrthosiphon pisum (Hemiptera: Aphididae) and degradation by enzymes from the aphid gut. Regul Pept. 2011 Nov 10;171(1-3):11-8. doi: 10.1016/j.regpep.2011.05.013. Epub 2011 Jun 23. PubMed PMID: 21704083. 18: Mousley A, Marks NJ, Halton DW, Geary TG, Thompson DP, Maule AG. Arthropod FMRFamide-related peptides modulate muscle activity in helminths. Int J Parasitol. 2004 May;34(6):755-68. PubMed PMID: 15111097. 19: Konno K, Kazuma K, Nihei K. Peptide Toxins in Solitary Wasp Venoms. Toxins (Basel). 2016 Apr 18;8(4):114. doi: 10.3390/toxins8040114. Review. PubMed PMID: 27096870; PubMed Central PMCID: PMC4848640. 20: Matthews HJ, Audsley N, Weaver RJ. In vitro and in vivo effects of myo-active peptides on larvae of the tomato moth Lacanobia oleracea and the cotton leaf worm Spodoptera littoralis (Lepidoptera; Noctuidae). Arch Insect Biochem Physiol. 2008 Oct;69(2):60-9. doi: 10.1002/arch.20265. PubMed PMID: 18780345.