DNMDP | CAS#328104-79-6 | PDE3A modulator

MedKoo Cat#: 527696 | Name: DNMDP

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DNMDP is a novel cancer-cytotoxic modulator of PDE3A.

Chemical Structure

DNMDP

CAS#328104-79-6

Theoretical Analysis

MedKoo Cat#: 527696

Name: DNMDP

CAS#: 328104-79-6

Chemical Formula: C15H20N4O3

Exact Mass: 304.1535

Molecular Weight: 304.35

Elemental Analysis: C, 59.20; H, 6.62; N, 18.41; O, 15.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

DNMDP

IUPAC/Chemical Name

6-(4-(Diethylamino)-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

InChi Key

YOSSKNZHADPXJX-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H20N4O3/c1-4-18(5-2)12-7-6-11(9-13(12)19(21)22)15-10(3)8-14(20)16-17-15/h6-7,9-10H,4-5,8H2,1-3H3,(H,16,20)

SMILES Code

O=C1CC(C)C(C2=CC=C(N(CC)CC)C([N+]([O-])=O)=C2)=NN1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 304.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rhee DK, Hockman SC, Choi SK, Kim YE, Park C, Manganiello VC, Kim KK. SFPQ, a multifunctional nuclear protein, regulates the transcription of PDE3A. Biosci Rep. 2017 Jul 25. pii: BSR20170975. doi: 10.1042/BSR20170975. [Epub ahead of print] PubMed PMID: 28743736; PubMed Central PMCID: PMC5548871. 2: Vandenberghe P, Hagué P, Hockman SC, Manganiello VC, Demetter P, Erneux C, Vanderwinden JM. Phosphodiesterase 3A: a new player in development of interstitial cells of Cajal and a prospective target in gastrointestinal stromal tumors (GIST). Oncotarget. 2017 Jun 20;8(25):41026-41043. doi: 10.18632/oncotarget.17010. PubMed PMID: 28454120; PubMed Central PMCID: PMC5522287. 3: de Waal L, Lewis TA, Rees MG, Tsherniak A, Wu X, Choi PS, Gechijian L, Hartigan C, Faloon PW, Hickey MJ, Tolliday N, Carr SA, Clemons PA, Munoz B, Wagner BK, Shamji AF, Koehler AN, Schenone M, Burgin AB, Schreiber SL, Greulich H, Meyerson M. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nat Chem Biol. 2016 Feb;12(2):102-8. doi: 10.1038/nchembio.1984. Epub 2015 Dec 14. PubMed PMID: 26656089; PubMed Central PMCID: PMC4718766.