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MedKoo Cat#: 563127 | Name: DNDS
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

DNDS is a voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel blocker.

Chemical Structure

DNDS
DNDS
CAS#3709-43-1

Theoretical Analysis

MedKoo Cat#: 563127

Name: DNDS

CAS#: 3709-43-1

Chemical Formula: C14H8N2Na2O10S2

Exact Mass: 473.9416

Molecular Weight: 474.32

Elemental Analysis: C, 35.45; H, 1.70; N, 5.91; Na, 9.69; O, 33.73; S, 13.52

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
25g USD 450.00 2 Weeks
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Related CAS #
No Data
Synonym
DNDS; DNDS (disodium); NSC-163175; NSC163175; NSC 163175;
IUPAC/Chemical Name
Disodium 5-nitro-2-[(E)-2-(4-nitro-2-sulfonatophenyl)ethenyl]benzenesulfonate
InChi Key
SDCDTWFAOKXZHD-SEPHDYHBSA-L
InChi Code
InChI=1S/C14H10N2O10S2.2Na/c17-15(18)11-5-3-9(13(7-11)27(21,22)23)1-2-10-4-6-12(16(19)20)8-14(10)28(24,25)26;;/h1-8H,(H,21,22,23)(H,24,25,26);;/q;2*+1/p-2/b2-1+;;
SMILES Code
O=S(C1=CC([N+]([O-])=O)=CC=C1/C=C/C2=CC=C([N+]([O-])=O)C=C2S(=O)([O-])=O)([O-])=O.[Na+].[Na+]
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
DNDS is a voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel blocker.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 474.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Kramer AH. Statins in the management of aneurysmal subarachnoid hemorrhage: an overview of animal research, observational studies, randomized controlled trials and meta-analyses. Acta Neurochir Suppl. 2011;110(Pt 2):193-201. doi: 10.1007/978-3-7091-0356-2_36. Review. PubMed PMID: 21125471. 2: Simard JM, Schreibman D, Aldrich EF, Stallmeyer B, Le B, James RF, Beaty N. Unfractionated heparin: multitargeted therapy for delayed neurological deficits induced by subarachnoid hemorrhage. Neurocrit Care. 2010 Dec;13(3):439-49. doi: 10.1007/s12028-010-9435-1. Review. PubMed PMID: 20809188; PubMed Central PMCID: PMC3012204. 3: Kramer AH, Fletcher JJ. Locally-administered intrathecal thrombolytics following aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. Neurocrit Care. 2011 Jun;14(3):489-99. doi: 10.1007/s12028-010-9429-z. Review. PubMed PMID: 20740327. 4: Singh AK, Venglarik CJ, Bridges RJ. Development of chloride channel modulators. Kidney Int. 1995 Oct;48(4):985-93. Review. PubMed PMID: 8569108.