MedKoo Cat#: 318801 | Name: Tenoxicam
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID). It was originated by Roche but as of 2008 is sold by Meda AB under the trade name Mobiflex.

Chemical Structure

Tenoxicam
Tenoxicam
CAS#59804-37-4

Theoretical Analysis

MedKoo Cat#: 318801

Name: Tenoxicam

CAS#: 59804-37-4

Chemical Formula: C13H11N3O4S2

Exact Mass: 337.0191

Molecular Weight: 337.37

Elemental Analysis: C, 46.28; H, 3.29; N, 12.46; O, 18.97; S, 19.01

Price and Availability

Size Price Availability Quantity
100mg USD 150.00
200mg USD 250.00
500mg USD 450.00
1g USD 750.00
2g USD 1,050.00
5g USD 1,950.00
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Related CAS #
No Data
Synonym
BRN-0572193; BRN0572193; BRN 0572193; Tenoxicam; Liman; Octiveran
IUPAC/Chemical Name
4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide
InChi Key
LZNWYQJJBLGYLT-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
SMILES Code
O=C(C1=C(O)C2=C(C=CS2)S(N1C)(=O)=O)NC3=NC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 337.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Individual NSAIDs and upper gastrointestinal complications: a systematic review and meta-analysis of observational studies (the SOS project). Drug Saf. 2012 Dec 1;35(12):1127-46. doi: 10.2165/11633470-000000000-00000. Review. PubMed PMID: 23137151; PubMed Central PMCID: PMC3714137. 5: Salat K, Moniczewski A, Librowski T. Nitrogen, oxygen or sulfur containing heterocyclic compounds as analgesic drugs used as modulators of the nitroxidative stress. Mini Rev Med Chem. 2013 Mar;13(3):335-52. Review. PubMed PMID: 22876956. 6: Bennett MH, Lehm JP, Mitchell SJ, Wasiak J. Recompression and adjunctive therapy for decompression illness. Cochrane Database Syst Rev. 2012 May 16;5:CD005277. doi: 10.1002/14651858.CD005277.pub3. Review. PubMed PMID: 22592704. 7: Jaturapatporn D, Isaac MG, McCleery J, Tabet N. Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease. Cochrane Database Syst Rev. 2012 Feb 15;2:CD006378. doi: 10.1002/14651858.CD006378.pub2. Review. PubMed PMID: 22336816. 8: Moore RA, Derry S, McQuay HJ, Wiffen PJ. Single dose oral analgesics for acute postoperative pain in adults. Cochrane Database Syst Rev. 2011 Sep 7;(9):CD008659. doi: 10.1002/14651858.CD008659.pub2. Review. Update in: Cochrane Database Syst Rev. 2015;9:CD008659. PubMed PMID: 21901726; PubMed Central PMCID: PMC4160790. 9: Xiaoting L, Yin T, Yangxi C. Interventions for pain during fixed orthodontic appliance therapy. A systematic review. Angle Orthod. 2010 Sep;80(5):925-32. doi: 10.2319/010410-10.1. Review. PubMed PMID: 20578865. 10: Bennett MH, Lehm JP, Mitchell SJ, Wasiak J. Recompression and adjunctive therapy for decompression illness: a systematic review of randomized controlled trials. Anesth Analg. 2010 Sep;111(3):757-62. doi: 10.1213/ANE.0b013e3181cdb081. Epub 2010 Mar 23. Review. PubMed PMID: 20332190. 11: Ong CK, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010 Apr 1;110(4):1170-9. doi: 10.1213/ANE.0b013e3181cf9281. Epub 2010 Feb 8. Review. PubMed PMID: 20142348. 12: Moore OA, McIntyre M, Moore RA, Derry S, McQuay HJ. Single dose oral tenoxicam for acute postoperative pain in adults. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD007591. doi: 10.1002/14651858.CD007591.pub2. Review. PubMed PMID: 19588438; PubMed Central PMCID: PMC4175441. 13: Agúndez JA, García-Martín E, Martínez C. Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine? Expert Opin Drug Metab Toxicol. 2009 Jun;5(6):607-20. doi: 10.1517/17425250902970998 . Review. PubMed PMID: 19422321. 14: Watson M, Brookes ST, Faulkner A, Kirwan J. WITHDRAWN: Non-aspirin, non-steroidal anti-inflammatory drugs for treating osteoarthritis of the knee. Cochrane Database Syst Rev. 2007 Jul 18;(1):CD000142. Review. PubMed PMID: 17636601. 15: Bennett MH, Lehm JP, Mitchell SJ, Wasiak J. Recompression and adjunctive therapy for decompression illness. Cochrane Database Syst Rev. 2007 Apr 18;(2):CD005277. Review. Update in: Cochrane Database Syst Rev. 2012;5:CD005277. PubMed PMID: 17443579. 16: Rodrigues AD. Impact of CYP2C9 genotype on pharmacokinetics: are all cyclooxygenase inhibitors the same? Drug Metab Dispos. 2005 Nov;33(11):1567-75. Epub 2005 Aug 23. Review. PubMed PMID: 16118328. 17: Heintjes E, Berger MY, Bierma-Zeinstra SM, Bernsen RM, Verhaar JA, Koes BW. Pharmacotherapy for patellofemoral pain syndrome. Cochrane Database Syst Rev. 2004;(3):CD003470. Review. PubMed PMID: 15266488. 18: Neher JO, Safranek S, Greenwald JL. Clinical inquiries. What is the best therapy for superficial thrombophlebitis? J Fam Pract. 2004 Jul;53(7):583-5. Review. PubMed PMID: 15251103. 19: Richy F, Bruyere O, Ethgen O, Rabenda V, Bouvenot G, Audran M, Herrero-Beaumont G, Moore A, Eliakim R, Haim M, Reginster JY. Time dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approach. Ann Rheum Dis. 2004 Jul;63(7):759-66. Review. PubMed PMID: 15194568; PubMed Central PMCID: PMC1755051. 20: Legrand E. Aceclofenac in the management of inflammatory pain. Expert Opin Pharmacother. 2004 Jun;5(6):1347-57. Review. PubMed PMID: 15163279.