Proscillaridin | CAS#466-06-8 | cardiotonic glycoside

MedKoo Cat#: 561872 | Name: Proscillaridin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Proscillaridin, also known as Proscillaridin A, is a cardiotonic glycoside which potently disrupts topoisomerase I and II activity. Proscillaridin A synergistically enhances TRAIL-induced cell death in TRAIL-sensitive and -resistant colon cancer cells. Proscillaridin A potentially inhibits lung cancer cell growth and motility by regulating EGFR-Src-associated pathways.

Chemical Structure

Proscillaridin

CAS#466-06-8

Theoretical Analysis

MedKoo Cat#: 561872

Name: Proscillaridin

CAS#: 466-06-8

Chemical Formula: C30H42O8

Exact Mass: 530.2880

Molecular Weight: 530.65

Elemental Analysis: C, 67.90; H, 7.98; O, 24.12

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 450.00	2 Weeks
25mg	USD 1,250.00	2 Weeks

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Related CAS #

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Synonym

Proscillaridin; Proscillaridin A; Proscillaridina; Caradrin;

IUPAC/Chemical Name

5-[(3S,8R,9S,10R,13R,14S,17R)-14-Hydroxy-10,13-dimethyl-3-[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy-1,2,3,6,7,8,9,11,12,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one

InChi Key

MYEJFUXQJGHEQK-ALRJYLEOSA-N

InChi Code

InChI=1S/C30H42O8/c1-16-24(32)25(33)26(34)27(37-16)38-19-8-11-28(2)18(14-19)5-6-22-21(28)9-12-29(3)20(10-13-30(22,29)35)17-4-7-23(31)36-15-17/h4,7,14-16,19-22,24-27,32-35H,5-6,8-13H2,1-3H3/t16-,19-,20+,21-,22+,24-,25+,26+,27-,28-,29+,30-/m0/s1

SMILES Code

O=C1C=CC([C@H]2CC[C@]3(O)[C@]4([H])CCC5=C[C@@H](O[C@@H]6O[C@@H](C)[C@H](O)[C@@H](O)[C@H]6O)CC[C@]5(C)[C@@]4([H])CC[C@]23C)=CO1

Appearance

Solid powder

Purity

>90 % (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 530.65 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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