Synonym
Arthrex; Biarison; Proquazona; Proquazonum; Proquazone
IUPAC/Chemical Name
2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-
InChi Key
JTIGKVIOEQASGT-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H18N2O/c1-12(2)20-16-11-13(3)9-10-15(16)17(19-18(20)21)14-7-5-4-6-8-14/h4-12H,1-3H3
SMILES Code
O=C1N(C(C)C)C2=C(C=CC(C)=C2)C(C3=CC=CC=C3)=N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
278.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Mäkäräinen L, Ylikorkala O. Menstrual blood loss in dysmenorrhoea: effects of proquazone and indomethacin. Br J Obstet Gynaecol. 1983 Jun;90(6):570-2. PubMed PMID: 6134549.
2: von Orelli J, Leuenberger H. Search for technological reasons to develop a capsule or a tablet formulation with respect to wettability and dissolution. Int J Pharm. 2004 Dec 9;287(1-2):135-45. PubMed PMID: 15541920.
3: Roos A, Hinderling PH. Protein binding and erythrocyte partitioning of the antirheumatic proquazone. J Pharm Sci. 1981 Mar;70(3):252-7. PubMed PMID: 7264886.
4: Ohnhaus EE. The effect of antacid and food on the absorption of proquazone (Biarison) in man. Int J Clin Pharmacol Ther Toxicol. 1980 Mar;18(3):136-9. PubMed PMID: 7380586.
5: Ruotsi A, Vainio U. Treatment of acute gouty arthritis with proquazone and indomethacin. A comparative, double-blind trial. Scand J Rheumatol Suppl. 1978;(21):15-7. PubMed PMID: 356235.
6: Johansson EA, Niemi KM, Ranki A. Modification of lymphocyte subsets in Jessner's lymphocytic infiltration of the skin during proquazone treatment. Dermatologica. 1988;176(2):70-5. PubMed PMID: 3371522.
7: Akçil E, Yavuz G, Koçak M. Effects of inflammation and antiinflammatory treatment on serum trace elements concentrations. Biol Trace Elem Res. 2003 Summer;93(1-3):95-104. PubMed PMID: 12835494.
8: Ruotsi A, Skrifvars B. A long-term double-blind comparative study on proquazone (Biarison) and ibuprofen in rheumatoid arthritis. Scand J Rheumatol Suppl. 1978;(21):28-32. PubMed PMID: 356239.
9: Serry MM. Proquazone ('Biarison') in osteoarthritis of the knee: a double-blind, dose comparison trial. Pharmatherapeutica. 1980;2(5):323-9. PubMed PMID: 7001491.
10: Gábor M, Rázga Z. Effects of non-steroidal antiphlogistics on mouse ear oedema induced with dithranol. Acta Physiol Hung. 1990;75(4):287-91. PubMed PMID: 2075824.
11: Hassan EM, Gazy AA, Abdel-Hay MH, Belal TS. High-performance liquid chromatographic determination of proquazone and its m-hydroxy metabolite in spiked human plasma and urine. J AOAC Int. 2007 Jul-Aug;90(4):971-6. PubMed PMID: 17760334.
12: Mertz DP. [Ankylosing spondylitis. Pathogenesis and therapy]. Fortschr Med. 1981 Mar 19;99(11):394-8. German. PubMed PMID: 7227933.
13: Bragstad A. A comparative, double-blind trial with proquazone and naproxen in the treatment of rheumatoid arthritis. Scand J Rheumatol Suppl. 1978;(21):33-5. PubMed PMID: 356240.
14: Welling PG, Tse FL. Food interactions affecting the absorption of analgesic and anti-inflammatory agents. Drug Nutr Interact. 1983;2(3):153-68. Review. PubMed PMID: 6381014.
15: Gábor M, Rázga Z. Influence of nonsteroidal antiphlogistics on mouse ear inflammation induced with croton oil. Arch Int Pharmacodyn Ther. 1989 May-Jun;299:241-6. PubMed PMID: 2774767.
16: Nissilä M, Kajander A. Proquazone (Biarison) and indomethacin (Indocid) in the treatment of ankylosing spondylitis. Two comparative, clinical, double-blind studies. Scand J Rheumatol Suppl. 1978;(21):36-9. PubMed PMID: 356241.
17: Brewer EJ, Giannini EH, Baum J, Fink CW, Hanson V, Jacobs JC, Schaller JG. Proquazone (Biarsan) in the treatment of juvenile rheumatoid arthritis. A segment I study. J Rheumatol. 1982 Jan-Feb;9(1):135-9. PubMed PMID: 7086771.
18: Forbes JA, White RW, White EH, Hughes MK. An evaluation of the analgesic efficacy of proquazone and aspirin in postoperative dental pain. J Clin Pharmacol. 1980 Jul;20(7):465-74. PubMed PMID: 7000855.
19: Franz JM, Gaillard A, Maibach HI, Schweitzer A. Percutaneous absorption of griseofulvin and proquazone in the rat and in isolated human skin. Arch Dermatol Res. 1981;271(3):275-82. PubMed PMID: 6975603.
20: Andersen RB, Halskov O. A double-blind clinical comparison of proquazone and naproxen in the treatment of patients with symptoms of lumbar nerve root compression syndrome. Scand J Rheumatol Suppl. 1978;(21):18-20. PubMed PMID: 356236.
