MedKoo Cat#: 562618 | Name: AS-HK014
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AS-HK014, also known as Gingerenone A, is a trypanocidal curcumin analog bearing a mono-enone linker motif act on Trypanosoma brucei by forming an adduct with trypanothione.

Chemical Structure

AS-HK014
AS-HK014
CAS#128700-97-0

Theoretical Analysis

MedKoo Cat#: 562618

Name: AS-HK014

CAS#: 128700-97-0

Chemical Formula: C21H24O5

Exact Mass: 356.1600

Molecular Weight: 356.42

Elemental Analysis: C, 70.77; H, 6.79; O, 22.44

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,250.00 2 Weeks
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Related CAS #
79067-88-2 81569-02-0 128700-97-0
Synonym
AS-HK014; AS HK014; ASHK014; Gingerenone A; Gingerenone-A; GingerenoneA;
IUPAC/Chemical Name
(4E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-4-hepten-3-one
InChi Key
FWDXZNKYDTXGOT-GQCTYLIASA-N
InChi Code
InChI=1S/C21H24O5/c1-25-20-13-15(8-11-18(20)23)5-3-4-6-17(22)10-7-16-9-12-19(24)21(14-16)26-2/h4,6,8-9,11-14,23-24H,3,5,7,10H2,1-2H3/b6-4+
SMILES Code
O=C(/C=C/CCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2
Appearance
A solution in ethanol
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 356.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Alkhaldi AA, Creek DJ, Ibrahim H, Kim DH, Quashie NB, Burgess KE, Changtam C, Barrett MP, Suksamrarn A, de Koning HP. Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on trypanosoma brucei by forming an adduct with trypanothione. Mol Pharmacol. 2015;87(3):451-64. doi: 10.1124/mol.114.096016. Epub 2014 Dec 19. PubMed PMID: 25527638.