BRD6989 is a selective CDK8 inhibitor. The ability of BRD6989 to upregulate IL-10 is recapitulated by multiple, structurally differentiated CDK8 and CDK19 inhibitors and requires an intact cyclin C-CDK8 complex. BRD6989 demonstrated a high selectivity for CDK8 over CDK19. In bone-marrow-derived dendritic cells, BRD6989 suppressed the phosphorylation of STAT1 at S727 and enhanced the production of IL-10, suggesting CDK8 as a negative regulator of IL-10 production during innate immune activation. BRD6989 may be useful for inflammatory disorders.
MedKoo Cat#: 407868
Name: BRD6989
CAS#: 642008-81-9
Chemical Formula: C16H16N4
Exact Mass: 264.1375
Molecular Weight: 264.33
Elemental Analysis: C, 72.70; H, 6.10; N, 21.20
The following data is based on the product molecular weight 264.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
