MedKoo Cat#: 596262 | Name: Iodoalphionic acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Iodoalphionic acid is the contrast medium, which was used for gallbladder examination. It is rarely appeared in the colon and, therefore, rarely masked the gallbladder. The density of the shadow produced by Iodoalphionic acid was greater than that produced by iodophthalein. It was reliable peroral cholecystographic medium, which was less objectionable to take and seldom causes vomiting. Diarrhoea occurred in some cases, but not more often than with tetraiodophenolphthalein. The ingestion of Iodoalphionic acid resulted in low thyroidal radioiodine accumulation for periods ranging from a few weeks to many months.

Chemical Structure

Iodoalphionic acid
Iodoalphionic acid
CAS#577-91-3 (free)

Theoretical Analysis

MedKoo Cat#: 596262

Name: Iodoalphionic acid

CAS#: 577-91-3 (free)

Chemical Formula: C15H12I2O3

Exact Mass: 493.8876

Molecular Weight: 494.06

Elemental Analysis: C, 36.47; H, 2.45; I, 51.37; O, 9.71

Price and Availability

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Synonym
Iodoalphionic acid; NSC 11854; NSC11854; NSC-11854; Pheniodolum; Tenamid; Biselectan;
IUPAC/Chemical Name
3-(4-hydroxy-3,5-diiodophenyl)-2-phenylpropanoic acid
InChi Key
IKYIXZSIKOYSLD-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H12I2O3/c16-12-7-9(8-13(17)14(12)18)6-11(15(19)20)10-4-2-1-3-5-10/h1-5,7-8,11,18H,6H2,(H,19,20)
SMILES Code
O=C(O)C(C1=CC=CC=C1)CC2=CC(I)=C(O)C(I)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 494.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Druzhinina OI, Sergeev PV, Byshevskiĭ ASh, Chabanov MK. [Effect of tri-iodine-containing x-ray contrast substances on the blood coagulation system in an experiment]. Farmakol Toksikol. 1984 Jul-Aug;47(4):63-5. Russian. PubMed PMID: 6479314. 2: Sergeev PV, Belykh AG. [Effect of contrast agents on the iodine-absorbing function of the thyroid gland]. Farmakol Toksikol. 1982 Mar-Apr;45(2):96-100. Russian. PubMed PMID: 7075759. 3: CUPP CM, NEWMAN S. Influence of iodoalphionic acid priodax, with and without thyrotropin, on thyroidal I 131 uptake in euthyroid patients. J Clin Endocrinol Metab. 1957 Jan;17(1):94-8. PubMed PMID: 13385321. 4: CLAUS E, BAEYENS J. [Comparative study of iodopanoic acid (telepaque) and iodoalphionic acid (pheniodol) in cholecystography; densitometric and plainimetric x-ray study of 100 cases]. J Radiol Electrol Arch Electr Medicale. 1954;35(7-8):554-9. French. PubMed PMID: 13222375. 5: DONCKASTER R, GODOY M, MORALES I. [Duodenal intubation of acranil and iodoalphionic acid in therapy of teniasis]. Bol Chil Parasitol. 1954 Jan-Mar;9(1):16-9. Spanish. PubMed PMID: 13189939. 6: CLAUS E, BAEYENS J. [Comparative cholecystographic study of iodopanoic acid (telepaque) and iodoalphionic acid]. J Belge Radiol. 1953;36(1):17-48. Undetermined Language. PubMed PMID: 13096516. 7: OSIMANI JJ. [Inefficacy of iodoalphionic acid in radical cure of taeniasis]. Arch Urug Med Cir Espec. 1952 Nov-Dec;41(5-6):275-81. Undetermined Language. PubMed PMID: 13066283. 8: ABEL MS, LOMHOFF II, GARCIA CV. Comparison of cholecystography with iodoalphionic acid (priodax) and a new gallbladder dye, iodopropanoic acid (telepaque). Perm Found Med Bull. 1952 Aug;10(1-4):95-101. PubMed PMID: 14948365.