Acriflavine Hydrochloride | CAS#8063-24-9 | HIF-1α inhibitor

MedKoo Cat#: 561728 | Name: Acriflavine Hydrochloride

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Acriflavine HCl is a mixture of 3,6-diaminoacridine (proflavin) and 3,6-diamino-10-methylacridinium (acriflavin). It is an inhibitor of HIF-1α. It acts by inducing cell death and apoptosis in several glioma cell lines, targeting HIF-1α-mediated pathways, and decreasing the level of PGK1, VEGF and HIF-1α in vitro and in vivo.

Chemical Structure

Acriflavine Hydrochloride

CAS#8063-24-9 (HCl)

Theoretical Analysis

MedKoo Cat#: 561728

Name: Acriflavine Hydrochloride

CAS#: 8063-24-9 (HCl)

Chemical Formula: C14H14ClN3 . C13H11N3. 2HCl

Exact Mass: 0.0000

Molecular Weight: 0.00

Elemental Analysis: C, 59.84; H, 5.02; Cl, 19.63; N, 15.51

Price and Availability

Size	Price	Availability	Quantity
10g	USD 250.00	2 Weeks
25g	USD 450.00	2 Weeks

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Related CAS #

8063-24-9 (HCl) 8048-52-0 (Cl)

Synonym

Acriflavine Hydrochloride; Acriflavine HCl; 3,6-Diamino-10-methylacridinium chloride hydrochloride, Euflavine

IUPAC/Chemical Name

3,6-Diamino-10-methylacridinium chloride hydrochloride + acridine-3,6-diamine hydrochloride

InChi Key

MKLTXAHQKDVBLY-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H13N3.C13H11N3.3ClH/c1-17-13-7-11(15)4-2-9(13)6-10-3-5-12(16)8-14(10)17;14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;;;/h2-8H,1H3,(H3,15,16);1-7H,14-15H2;3*1H

SMILES Code

Cl[H].Cl[H].NC1=CC2=NC3=C(C=CC(N)=C3)C=C2C=C1.C[N+]4=C5C=C(C=CC5=CC6=C4C=C(N)C=C6)N.[Cl-]

Appearance

Solid powder

Purity

Acriflavine HCl: 10-50%; Proflavine HCl: 25-70%

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 0.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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