MedKoo Cat#: 126026 | Name: GSK25
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK25 is an inhibitor of Rho-associated kinase 1 (ROCK1; IC50 = 7 nM for the human kinase).

Chemical Structure

GSK25
GSK25
CAS#874119-56-9

Theoretical Analysis

MedKoo Cat#: 126026

Name: GSK25

CAS#: 874119-56-9

Chemical Formula: C24H16Cl2F2N6O

Exact Mass: 512.0731

Molecular Weight: 513.33

Elemental Analysis: C, 56.16; H, 3.14; Cl, 13.81; F, 7.40; N, 16.37; O, 3.12

Price and Availability

Size Price Availability Quantity
1mg USD 450.00 2 Weeks
5mg USD 850.00 2 Weeks
10mg USD 1,350.00 2 Weeks
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Related CAS #
No Data
Synonym
GSK25; GSK-25; GSK 25; Dihydropyrimidine, 25
IUPAC/Chemical Name
4-(4-chloro-2-fluorophenyl)-2-(2-chloropyridin-4-yl)-N-(6-fluoro-1H-indazol-5-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxamide
InChi Key
KZYAHEIPPAPADQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H16Cl2F2N6O/c1-11-21(24(35)32-19-6-13-10-30-34-18(13)9-17(19)28)22(15-3-2-14(25)8-16(15)27)33-23(31-11)12-4-5-29-20(26)7-12/h2-10,22H,1H3,(H,30,34)(H,31,33)(H,32,35)
SMILES Code
CC1=C(C(N=C(N1)C2=CC(=NC=C2)Cl)C3=C(C=C(C=C3)Cl)F)C(=O)NC4=C(C=C5C(=C4)C=NN5)F
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 513.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL