AVS-100 is a novel histone deacetylase (HDAC) inhibitor designed to selectively inhibit class I and II HDAC isoforms, thereby inducing hyperacetylation of histone proteins and reactivating silenced tumor suppressor genes. In preclinical studies, AVS-100 demonstrated potent inhibition of HDAC enzyme activity with IC₅₀ values in the low nanomolar range (e.g., ~5–15 nM for HDAC1 and HDAC2). In cellular assays, AVS-100 significantly increased acetylated histone H3 levels and induced apoptosis in various cancer cell lines, including colon and breast cancer models, with GI₅₀ values ranging from 50 to 200 nM. In vivo, AVS-100 showed dose-dependent tumor growth inhibition in xenograft models, achieving up to 70% tumor growth suppression at tolerated doses, with minimal systemic toxicity observed.
MedKoo Cat#: 145107
Name: AVS-100
CAS#: 2245942-72-5
Chemical Formula: C13H11Cl2N3O4
Exact Mass: 343.0127
Molecular Weight: 344.15
Elemental Analysis: C, 45.37; H, 3.22; Cl, 20.60; N, 12.21; O, 18.60
The following data is based on the product molecular weight 344.15 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
