PRX-07034 HCl | CAS#903580-39-2 | 5-HT6 receptor antagonist

MedKoo Cat#: 561674 | Name: PRX-07034 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PRX-07034 is a selective 5-HT6 receptor antagonist.

Chemical Structure

PRX-07034 HCl

CAS#903580-39-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 561674

Name: PRX-07034 HCl

CAS#: 903580-39-2 (HCl)

Chemical Formula: C21H29Cl2N3O4S

Exact Mass: 0.0000

Molecular Weight: 490.44

Elemental Analysis: C, 51.43; H, 5.96; Cl, 14.46; N, 8.57; O, 13.05; S, 6.54

Price and Availability

Size	Price	Availability
50mg	USD 450.00	2 Weeks
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 1,950.00	2 Weeks
1g	USD 2,950.00	2 Weeks
2g	USD 5,250.00	2 Weeks

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Related CAS #

903580-16-5 (free base) 903580-39-2 (HCl)

Synonym

PRX-07034; PRX07034; PRX 07034; PRX-07034 HCl; PRX-07034 hydrochloride.

IUPAC/Chemical Name

N-[1-(5-Chloro-2,3-dimethoxyphenyl)ethyl]-2-methylsulfonyl-5-piperazin-1-ylaniline hydrochloride

InChi Key

PILCQJJJAFRKHO-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H28ClN3O4S.ClH/c1-14(17-11-15(22)12-19(28-2)21(17)29-3)24-18-13-16(25-9-7-23-8-10-25)5-6-20(18)30(4,26)27;/h5-6,11-14,23-24H,7-10H2,1-4H3;1H

SMILES Code

O=S(C1=CC=C(N2CCNCC2)C=C1NC(C3=CC(Cl)=CC(OC)=C3OC)C)(C)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO and water

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

PRX-07034 HCl is a highly selective and potent 5-HT6 receptor antagonist with a Ki= 4-8 nM and an IC50 of 19 nM. PRX-07034 can be used for the research of enhancing working memory and cognitive flexibility.

In vitro activity:

To be determined

In vivo activity:

The results of this study indicate that PRX-07034 exhibited high selectivity for the 5-HT(6) receptor and effectively antagonized its activity. In rats, PRX-07034 improved delayed spontaneous alternation and enhanced the ability to switch between place and response strategies. PRX-07034 is a potent (Ki = 4-8 nM) and highly selective 5-HT(6) receptor antagonist (≥100-fold selectivity for the 5-HT(6) receptor compared to 68 other GPCRs). For cyclic AMP quantification, PRX-07034 had antagonist activity (IC(50) = 19 nM.) Reference: Psychopharmacology (Berl). 2012 Apr;220(4):687-96. https://pubmed.ncbi.nlm.nih.gov/21989804/

	Solvent	mg/mL	mM
Solubility
	DMSO	31.3	63.72
	Water	4.8	9.71

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 490.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Abraham R, Nirogi R, Shinde A, Irupannanavar S. Low-dose prazosin in combination with 5-HT6 antagonist PRX-07034 has antipsychotic effects. Can J Physiol Pharmacol. 2015 Jan;93(1):13-21. doi: 10.1139/cjpp-2014-0254. PMID: 25429515. 2. Mohler EG, Baker PM, Gannon KS, Jones SS, Shacham S, Sweeney JA, Ragozzino ME. The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology (Berl). 2012 Apr;220(4):687-96. doi: 10.1007/s00213-011-2518-7. Epub 2011 Oct 12. PMID: 21989804; PMCID: PMC3636983.

In vitro protocol:

To be determined

In vivo protocol:

1: Abraham R, Nirogi R, Shinde A, Irupannanavar S. Low-dose prazosin in combination with 5-HT6 antagonist PRX-07034 has antipsychotic effects. Can J Physiol Pharmacol. 2015 Jan;93(1):13-21. doi: 10.1139/cjpp-2014-0254. PMID: 25429515. 2: Mohler EG, Baker PM, Gannon KS, Jones SS, Shacham S, Sweeney JA, Ragozzino ME. The effects of PRX-07034, a novel 5-HT6 antagonist, on cognitive flexibility and working memory in rats. Psychopharmacology (Berl). 2012 Apr;220(4):687-96. doi: 10.1007/s00213-011-2518-7. Epub 2011 Oct 12. PMID: 21989804; PMCID: PMC3636983. 3: Fone KC. An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function. Neuropharmacology. 2008 Nov;55(6):1015-22. doi: 10.1016/j.neuropharm.2008.06.061. Epub 2008 Jul 4. PMID: 18655798. 4: Halford JC, Harrold JA, Boyland EJ, Lawton CL, Blundell JE. Serotonergic drugs : effects on appetite expression and use for the treatment of obesity. Drugs. 2007;67(1):27-55. doi: 10.2165/00003495-200767010-00004. PMID: 17209663.