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MedKoo Cat#: 328096 | Name: Proxodolol hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Proxodolol is a β-adrenergic receptor antagonist potentially for the treatment of glaucoma, hypertension and angina.

Chemical Structure

Proxodolol hydrochloride
Proxodolol hydrochloride
CAS#152289-59-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 328096

Name: Proxodolol hydrochloride

CAS#: 152289-59-3 (HCl)

Chemical Formula: C17H26ClN3O4

Exact Mass:

Molecular Weight: 371.86

Elemental Analysis: C, 54.91; H, 7.05; Cl, 9.53; N, 11.30; O, 17.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Proxodolol hydrochloride;
IUPAC/Chemical Name
1-(tert-butylamino)-3-(2-((3-methyl-1,2,4-oxadiazol-5-yl)methoxy)phenoxy)propan-2-ol hydrochloride
InChi Key
IJFQPJLVRULPKP-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H25N3O4.ClH/c1-12-19-16(24-20-12)11-23-15-8-6-5-7-14(15)22-10-13(21)9-18-17(2,3)4;/h5-8,13,18,21H,9-11H2,1-4H3;1H
SMILES Code
OC(COC1=CC=CC=C1OCC2=NC(C)=NO2)CNC(C)(C)C.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 152289-58-2 (Proxodolol Free) 152289-59-3 (Proxodolol hydrochloride)

Preparing Stock Solutions

The following data is based on the product molecular weight 371.86 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Beliaeva SA. [Efficacy and safety of the first made in Russia αβ long-acting adrenoblocker proxodolol in patients with arterial hypertension of the second degree]. Ter Arkh. 2011;83(4):52-5. Russian. PubMed PMID: 21675275. 2: Shashurin DA, Timoshin AA, Medvedev OS, Vanin AF. [Effects of carvedilol and proxodolol on nitric oxide (NO) metabolism in various organs in a congestive heart failure model]. Eksp Klin Farmakol. 2011;74(1):19-23. Russian. PubMed PMID: 21476270. 3: Ol'binskaia LI, Sizova ZhM. [Efficacy and Safety of a Domestic Non-selective b-adrenoblocker Possibilities of the Use of Proxodolol in the Treatment of Patients With Chronic Heart Failure.]. Kardiologiia. 2006;46(12):17-20. Russian. PubMed PMID: 17310958. 4: Shashurin DA, Medvedev OS, Iuzhakov SD. [Studying the effect of the new beta-adrenoreceptor blocker proxodolol on the ischemic model of cardiac insufficiency]. Eksp Klin Farmakol. 2006 Mar-Apr;69(2):27-33. Russian. PubMed PMID: 16845936. 5: Iskenderov BG, Tatarchenko IP, Shevyrev VA. [Cardio-hemodynamic effects of domestic adrenergic beta-antagonist proxodolol in hypertension in patients with pacemaker]. Klin Med (Mosk). 1999;77(4):29-31. Russian. PubMed PMID: 10356914. 6: Ermakova VN, Malinina SL, Abdulkadyrova MZh, Filippova OM, Maliuta GD. [Therapy of patients with primary open-angle glaucoma with proxofelin, a combined form of proxodolol]. Vestn Oftalmol. 1999 Jan-Feb;115(1):3-5. Russian. PubMed PMID: 10207309. 7: Ermakova VN, Iuzhakov SD, Mashkovskiĭ MD, Kolomoĭtseva EM. [Proxodolol, a new domestic preparation for lowering intraocular pressure in glaucoma]. Vestn Oftalmol. 1995 Apr-Jun;111(2):4-7. Russian. PubMed PMID: 7645180. 8: Ermakova VN. [A clinico-pharmacological study of an ophthalmic drug form of proxodolol]. Eksp Klin Farmakol. 1994 May-Jun;57(3):57-9. Russian. PubMed PMID: 7914124. 9: Petrov IN, Rumiantsev AS, Smirnov MV. [The pharmacodynamics of proxodolol when administered once and in a course of doses to patients with stenocardia of effort]. Eksp Klin Farmakol. 1994 May-Jun;57(3):54-7. Russian. PubMed PMID: 7914123. 10: Bochkareva EV, Kokurina EV, Metelitsa VI, Pankina VA. [The comparative efficacy of individually adjusted doses of proxodolol and propranolol for one-time and regular administration in stenocardia patients]. Eksp Klin Farmakol. 1994 May-Jun;57(3):51-4. Russian. PubMed PMID: 7914122. 11: Metelitsa VI, Martsevich SIu, Kozyreva MP, Slastnikova ID, Vakulovskaia MK. [The efficacy of proxodolol, a new beta-adrenoblockader with alpha-adrenoblockader properties, in its single use in patients with stable stenocardia of effort]. Eksp Klin Farmakol. 1994 May-Jun;57(3):47-50. Russian. PubMed PMID: 7914121. 12: Kukes VG, Starodubtsev AK, Smirnov MV, Petrov IN. [The pharmacodynamic and hypotensive efficacy of proxodolol in an acute drug test on hypertension patients]. Eksp Klin Farmakol. 1994 May-Jun;57(3):45-7. Russian. PubMed PMID: 7914120. 13: Ol'binskaia LI, Morozova TE. [The new Russian preparation proxodolol in the treatment of arterial hypertension]. Eksp Klin Farmakol. 1994 May-Jun;57(3):42-5. Russian. PubMed PMID: 7914119. 14: Metelitsa VI, Ostrovskaia TP, Duda SG, Shastun RS, Chel'dieva EIa, Simonov DV, Kalinin AL, Kekshina MS. [The efficacy of proxodolol in patients with stable arterial hypertension]. Eksp Klin Farmakol. 1994 May-Jun;57(3):38-42. Russian. PubMed PMID: 7914118. 15: Rumiantsev DO, Piotrovskiĭ VK, Metelitsa VI, Golovanova IV, Ermachenkov IA, Gus'kova TA. [Proxodolol pharmacokinetics in rats and rabbits]. Eksp Klin Farmakol. 1994 May-Jun;57(3):36-8. Russian. PubMed PMID: 7914117. 16: Dolgun OV, Martynova ER, Medvedev OS, Iuzhakov SD. [The effect of proxodolol on systemic and regional hemodynamics]. Eksp Klin Farmakol. 1994 May-Jun;57(3):33-6. Russian. PubMed PMID: 7914116. 17: Iuzhakov SD, Dolgun OV, Dorodnikova EV, Aniukhovskiĭ EP, Baldenkov GN, Rozenshtraukh LV, Medvedev OS, Mashkovskiĭ MD. [Proxodolol--a new beta- and alpha-adrenoblockader]. Eksp Klin Farmakol. 1994 May-Jun;57(3):30-3. Russian. PubMed PMID: 7914115.