Synonym
EMDB1; EMDB-1; EMDB 1
IUPAC/Chemical Name
(S)-1-(L-Tyrosyl)-N-((R)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-3-(4-chlorophenyl)-1-oxopropan-2-yl)pyrrolidine-2-carboxamide
InChi Key
DJWWRTNXHKEXNP-BPXGVECKSA-N
InChi Code
InChI=1S/C32H36ClN5O5/c33-23-12-8-22(9-13-23)19-27(30(41)36-26(29(35)40)18-20-5-2-1-3-6-20)37-31(42)28-7-4-16-38(28)32(43)25(34)17-21-10-14-24(39)15-11-21/h1-3,5-6,8-15,25-28,39H,4,7,16-19,34H2,(H2,35,40)(H,36,41)(H,37,42)/t25-,26-,27+,28-/m0/s1
SMILES Code
O=C([C@H]1N(C([C@H](CC2=CC=C(O)C=C2)N)=O)CCC1)N[C@H](CC3=CC=C(Cl)C=C3)C(N[C@@H](CC4=CC=CC=C4)C(N)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
606.12
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Salaga M, Binienda A, Draczkowski P, Kosson P, Kordek R, Jozwiak K, Fichna J. Novel peptide inhibitor of dipeptidyl peptidase IV (Tyr-Pro-D-Ala-NH(2)) with anti-inflammatory activity in the mouse models of colitis. Peptides. 2018 Oct;108:34-45. doi: 10.1016/j.peptides.2018.08.011. Epub 2018 Sep 1. PubMed PMID: 30179653.
2: Salaga M, Mokrowiecka A, Zielinska M, Malecka-Panas E, Kordek R, Kamysz E, Fichna J. New Peptide Inhibitor of Dipeptidyl Peptidase IV, EMDB-1 Extends the Half-Life of GLP-2 and Attenuates Colitis in Mice after Topical Administration. J Pharmacol Exp Ther. 2017 Oct;363(1):92-103. doi: 10.1124/jpet.117.242586. Epub 2017 Jul 19. PubMed PMID: 28724693.
3: Fichna J, Perlikowska R, Gach K, do-Rego JC, Cravezic A, Janecka A, Storr MA. The novel endomorphin degradation blockers Tyr-Pro-DClPhe-Phe-NH (EMDB-1) and Tyr-Pro-Ala-NH (EMDB-2) prolong endomorphin-2 action in rat ileum in vitro. Chem Biol Drug Des. 2010 Jul;76(1):77-81. doi: 10.1111/j.1747-0285.2010.00977.x. Epub 2010 Apr 23. PubMed PMID: 20456368.
