Bemnifosbuvir hemisulfate | CAS#2241337-84-6 | HCV viral replication inhibitor

MedKoo Cat#: 556029 | Name: Bemnifosbuvir hemisulfate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bemnifosbuvir hemisulfate, also known as AT-527 and RG 6422, a hemisulfate salt of AT-511, a guanosine nucleotide prodrug, is a potent and orally active HCV viral replication inhibitor. AT-511 is a prodrug form of the antiviral nucleoside analog AT-9010. It reduces the infectious virus yield in cells infected with Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome CoV (SARS-CoV), SARS-CoV-2, human CoV 229E (HCoV-229E), and HCoV-OC43 (EC90s = 37, 0.47, 2.8, 1.2, and 0.5 µM, respectively).

Chemical Structure

Bemnifosbuvir hemisulfate

CAS#2241337-84-6 (hemisulfate)

Theoretical Analysis

MedKoo Cat#: 556029

Name: Bemnifosbuvir hemisulfate

CAS#: 2241337-84-6 (hemisulfate)

Chemical Formula: C48H68F2N14O18P2S

Exact Mass: 0.0000

Molecular Weight: 1261.16

Elemental Analysis: C, 45.71; H, 5.44; F, 3.01; N, 15.55; O, 22.83; P, 4.91; S, 2.54

Price and Availability

Size	Price	Availability
10mg	USD 550.00	2 Weeks
25mg	USD 950.00	2 Weeks
50mg	USD 1,450.00	2 Weeks

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Related CAS #

1998705-64-8 (free base) 2241337-84-6 (hemisulfate) 2241337-80-2 (sulfate)

Synonym

AT 527; AT-527; AT527; RG 6422; RG-6422; RG6422; Bemnifosbuvir hemisulfate; AT-511 hemisulfate; AT511; AT-511

IUPAC/Chemical Name

isopropyl ((S)-(((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate hemisulfate

InChi Key

QIGYBLSWYRTXCA-NVSCJZCKSA-N

InChi Code

InChI=1S/2C24H33FN7O7P.H2O4S/c2*1-13(2)37-21(34)14(3)31-40(35,39-15-9-7-6-8-10-15)36-11-16-18(33)24(4,25)22(38-16)32-12-28-17-19(27-5)29-23(26)30-20(17)32;1-5(2,3)4/h2*6-10,12-14,16,18,22,33H,11H2,1-5H3,(H,31,35)(H3,26,27,29,30);(H2,1,2,3,4)/t2*14-,16+,18+,22+,24+,40-;/m00./s1

SMILES Code

C[C@@H](C(OC(C)C)=O)N[P@@](OC1=CC=CC=C1)(OC[C@H]2O[C@@H](N3C=NC4=C(NC)N=C(N)N=C34)[C@](C)(F)[C@@H]2O)=O.C[C@@H](C(OC(C)C)=O)N[P@@](OC5=CC=CC=C5)(OC[C@H]6O[C@@H](N7C=NC8=C(NC)N=C(N)N=C78)[C@](C)(F)[C@@H]6O)=O.O=S(O)(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,261.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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