XU1 | CAS#53439-81-9

MedKoo Cat#: 526596 | Name: XU1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

XU1 is a potent and selective pan Aurora inhibitor; Phosphorylation of histone H3 (pHH3) inhibitor.

Chemical Structure

XU1

CAS#53439-81-9

Theoretical Analysis

MedKoo Cat#: 526596

Name: XU1

CAS#: 53439-81-9

Chemical Formula: C12H8N2O

Exact Mass: 196.0637

Molecular Weight: 196.21

Elemental Analysis: C, 73.46; H, 4.11; N, 14.28; O, 8.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

XU1

IUPAC/Chemical Name

5H-Benzo[c][1,8]naphthyridin -6-one

InChi Key

YLSBDRGLLZDAKB-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H8N2O/c15-12-10-5-2-1-4-8(10)9-6-3-7-13-11(9)14-12/h1-7H,(H,13,14,15)

SMILES Code

O=C1NC2=NC=CC=C2C3=CC=CC=C13

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 196.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cui A, Rivailler P, Zhu Z, Deng X, Hu Y, Wang Y, Li F, Sun Z, He J, Si Y, Tian X, Zhou S, Lei Y, Zheng H, Rota PA, Xu W. Evolutionary analysis of mumps viruses of genotype F collected in mainland China in 2001-2015. Sci Rep. 2017 Dec 7;7(1):17144. doi: 10.1038/s41598-017-17474-z. PubMed PMID: 29215070; PubMed Central PMCID: PMC5719434. 2: Song J, Wang H, Shi J, Cui A, Huang Y, Sun L, Xiang X, Ma C, Yu P, Yang Z, Li Q, Ng TI, Zhang Y, Zhang R, Xu W. Emergence of BA9 genotype of human respiratory syncytial virus subgroup B in China from 2006 to 2014. Sci Rep. 2017 Dec 1;7(1):16765. doi: 10.1038/s41598-017-17055-0. PubMed PMID: 29196726; PubMed Central PMCID: PMC5711796. 3: Mao N, Zhu Z, Rivailler P, Chen M, Fan Q, Huang F, Xu W. Whole genomic analysis of two potential recombinant strains within Human mastadenovirus species C previously found in Beijing, China. Sci Rep. 2017 Nov 13;7(1):15380. doi: 10.1038/s41598-017-15336-2. PubMed PMID: 29133946; PubMed Central PMCID: PMC5684218. 4: Song Y, Zhang Y, Ji T, Gu X, Yang Q, Zhu S, Xu W, Xu Y, Shi Y, Huang X, Li Q, Deng H, Wang X, Yan D, Yu W, Wang S, Yu D, Xu W. Persistent circulation of Coxsackievirus A6 of genotype D3 in mainland of China between 2008 and 2015. Sci Rep. 2017 Jul 14;7(1):5491. doi: 10.1038/s41598-017-05618-0. PubMed PMID: 28710474; PubMed Central PMCID: PMC5511160. 5: Song J, Zhang Y, Wang H, Shi J, Sun L, Zhang X, Yang Z, Guan W, Zhang H, Yu P, Xie Z, Cui A, Ng TI, Xu W. Emergence of ON1 genotype of human respiratory syncytial virus subgroup A in China between 2011 and 2015. Sci Rep. 2017 Jul 14;7(1):5501. doi: 10.1038/s41598-017-04824-0. PubMed PMID: 28710393; PubMed Central PMCID: PMC5511225. 6: Xu S, Chen M, Zheng H, Wang H, Chen M, Zhou J, Shuang W, Yu P, Ma C, He J, Feng D, Zhen Z, Yan Z, Naiying M, Cui A, Wu Q, Qi M, Li C, Xu X, Xu W. Nationwide distribution of varicella-zoster virus clades in China. BMC Infect Dis. 2016 Oct 7;16(1):542. PubMed PMID: 27717328; PubMed Central PMCID: PMC5054591. 7: Yang Q, Zhang Y, Yan D, Zhu S, Wang D, Ji T, Huang W, An H, Xu W. Isolation of an imported subgenotype B5 strain of human enterovirus A71 in Chongqing City, China, 2014. Virol J. 2016 Jun 29;13:115. doi: 10.1186/s12985-016-0571-x. PubMed PMID: 27357279; PubMed Central PMCID: PMC4928301. 8: Rasulov BA, Rozi P, Pattaeva MA, Yili A, Aisa HA. Exopolysaccharide-Based Bioflocculant Matrix of Azotobacter chroococcum XU1 for Synthesis of AgCl Nanoparticles and Its Application as a Novel Biocidal Nanobiomaterial. Materials (Basel). 2016 Jun 29;9(7). pii: E528. doi: 10.3390/ma9070528. PubMed PMID: 28773650; PubMed Central PMCID: PMC5456945. 9: Xu W, Zhang Y. Isolation and Characterization of Vaccine-Derived Polioviruses, Relevance for the Global Polio Eradication Initiative. Methods Mol Biol. 2016;1387:213-26. doi: 10.1007/978-1-4939-3292-4_10. PubMed PMID: 26983736. 10: Xu H, Hu M, Yu X, Li Y, Fu Y, Zhou X, Zhang D, Li J. Design and evaluation of pH-sensitive liposomes constructed by poly(2-ethyl-2-oxazoline)-cholesterol hemisuccinate for doxorubicin delivery. Eur J Pharm Biopharm. 2015 Apr;91:66-74. doi: 10.1016/j.ejpb.2015.01.030. Epub 2015 Feb 7. PubMed PMID: 25660909. 11: Wang HB, Zhang LF, Yu WZ, Wen N, Yan DM, Tang JJ, Zhang Y, Fan CX, Reilly KH, Xu WB, Li L, Ding ZR, Luo HM. Cross-border collaboration between China and Myanmar for emergency response to imported vaccine derived poliovirus case. BMC Infect Dis. 2015 Jan 17;15:18. doi: 10.1186/s12879-015-0745-y. PubMed PMID: 25595618; PubMed Central PMCID: PMC4308939. 12: Xu W, Tan X. [Discussion on the vaccination strategy of enterovirus type 71 vaccine]. Zhonghua Yu Fang Yi Xue Za Zhi. 2014 Jun;48(6):443-4. Chinese. PubMed PMID: 25219429. 13: Xu S, Zhang Y, Rivailler P, Wang H, Ji Y, Zhen Z, Mao N, Li C, Bellini WJ, Xu W, Rota PA. Evolutionary genetics of genotype H1 measles viruses in China from 1993 to 2012. J Gen Virol. 2014 Sep;95(Pt 9):1892-9. doi: 10.1099/vir.0.066746-0. Epub 2014 Jun 9. PubMed PMID: 24914068; PubMed Central PMCID: PMC4135087. 14: Yan D, Zhang Y, Zhu S, Chen N, Li X, Wang D, Ma X, Zhu H, Tong W, Xu W. Limited and localized outbreak of newly emergent type 2 vaccine-derived poliovirus in Sichuan, China. Clin Vaccine Immunol. 2014 Jul;21(7):1012-8. doi: 10.1128/CVI.00196-14. Epub 2014 May 21. PubMed PMID: 24850620; PubMed Central PMCID: PMC4097442. 15: Zhang Y, Hong M, Sun Q, Zhu S, Tsewang, Li X, Yan D, Wang D, Xu W. Molecular typing and characterization of a new serotype of human enterovirus (EV-B111) identified in China. Virus Res. 2014 Apr;183:75-80. doi: 10.1016/j.virusres.2014.01.002. Epub 2014 Feb 3. PubMed PMID: 24503225. 16: Cui A, Zhu Z, Chen M, Zheng H, Liu L, Wang Y, Ma Y, Wang C, Fang X, Li P, Guan R, Wang S, Zhou J, Zheng L, Gao H, Ding Z, Li L, Bo F, Sun Z, Zhang Z, Feng D, He J, Chen H, Jin L, Rota PA, Xu W. Epidemiologic and genetic characteristics of mumps viruses isolated in China from 1995 to 2010. Infect Genet Evol. 2014 Jan;21:384-90. doi: 10.1016/j.meegid.2013.12.005. Epub 2013 Dec 17. PubMed PMID: 24355245. 17: Xu K, Butlin M, Avolio AP. Assessment of hemodynamic load components affecting optimization of cardiac resynchronization therapy by lumped parameter mode. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:6661-4. doi: 10.1109/EMBC.2012.6347522. PubMed PMID: 23367457. 18: Xu H, Deng YH, Wang KQ, Chen DW. Preparation and characterization of stable pH-sensitive vesicles composed of α-tocopherol hemisuccinate. AAPS PharmSciTech. 2012 Dec;13(4):1377-85. doi: 10.1208/s12249-012-9863-7. Epub 2012 Oct 3. PubMed PMID: 23054989; PubMed Central PMCID: PMC3513435. 19: Xu K, Butlin M, Avolio AP. Effects of pressure-dependent segmental arterial compliance and postural changes on pulse wave transmission in an arterial model of the human upper limb. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:6450-3. doi: 10.1109/IEMBS.2011.6091592. PubMed PMID: 22255815. 20: Calvet JP, Myers JA. In-vivo secondary structure analysis of the small nuclear RNA U1 using psoralen cross-linking. J Mol Biol. 1987 Oct 5;197(3):543-53. PubMed PMID: 3441011.