XY123 is a Potent, Selective, and Orally Available RORγ Inverse Agonist. XY123 potently inhibited the RORγ transcription activity with a half-maximal inhibitory concentration (IC50) value of 64 nM and showed excellent selectivity against other nuclear receptors. XY123 also potently suppressed cell proliferation, colony formation, and the expression of androgen receptor (AR)-regulated genes in AR-positive prostate cancer cell lines.
MedKoo Cat#: 464845
Name: XY123
CAS#: unknown
Chemical Formula: C32H27F4N3O3S
Exact Mass: 609.1709
Molecular Weight: 609.64
Elemental Analysis: C, 63.05; H, 4.46; F, 12.47; N, 6.89; O, 7.87; S, 5.26
The following data is based on the product molecular weight 609.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
