Synonym
N-Demethyldiltiazem; N-Desmethyldiltiazem; 85100-17-0; N-Monodemethyldiltiazem; 86408-45-9;
IUPAC/Chemical Name
(2S,3S)-2-(4-methoxyphenyl)-5-(2-(methylamino)ethyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
InChi Key
YOMLDISQSWWYOT-UXHICEINSA-N
InChi Code
InChI=1S/C21H24N2O4S/c1-14(24)27-19-20(15-8-10-16(26-3)11-9-15)28-18-7-5-4-6-17(18)23(21(19)25)13-12-22-2/h4-11,19-20,22H,12-13H2,1-3H3/t19-,20+/m1/s1
SMILES Code
CNCCN1C2=CC=CC=C2S[C@H]([C@@H](OC(C)=O)C1=O)C3=CC=C(OC)C=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
400.49
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Boyd RA, Chin SK, Don-Pedro O, Verotta D, Sheiner LB, Williams RL, Giacomini
KM. The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites
in healthy adults after a single oral dose. Clin Pharmacol Ther. 1989
Oct;46(4):408-19. doi: 10.1038/clpt.1989.159. PMID: 2791444.
2: Andrén L, Höglund P, Dotevall A, Eggertsen R, Svensson A, Olson SO, Wadenvik
H. Diltiazem in hypertensive patients with type II diabetes mellitus. Am J
Cardiol. 1988 Oct 5;62(11):114G-120G. doi: 10.1016/0002-9149(88)90043-4. PMID:
3177228.
3: Bregante MA, Aramayona JJ, Fraile LJ, Garcia MA, Solans C. Diltiazem blood
pharmacokinetics in the pregnant and non-pregnant rabbit: maternal and foetal
tissue levels. Xenobiotica. 2000 Aug;30(8):831-41. doi:
10.1080/00498250050119871. PMID: 11037114.
4: Sigusch H, Henschel L, Kraul H, Merkel U, Hoffmann A. Lack of effect of
grapefruit juice on diltiazem bioavailability in normal subjects. Pharmazie.
1994 Sep;49(9):675-9. PMID: 7972311.
5: Höglund P, Nilsson LG. Pharmacokinetics of diltiazem and its metabolites
after repeated single dosing in healthy volunteers. Ther Drug Monit. 1989
Sep;11(5):551-7. PMID: 2815230.
6: Höglund P, Nilsson LG. Pharmacokinetics of diltiazem and its metabolites
after single and multiple dosing in healthy volunteers. Ther Drug Monit. 1989
Sep;11(5):558-66. PMID: 2815231.
7: Hussain MD, Tam YK, Finegan BA, Coutts RT. Simple and sensitive high-
performance liquid chromatographic method for the determination of diltiazem and
six of its metabolites in human plasma. J Chromatogr. 1992 Nov 6;582(1-2):203-9.
doi: 10.1016/0378-4347(92)80320-p. PMID: 1491042.
