MedKoo Cat#: 561647 | Name: Quinine sulfate dihydrate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Quinine sulfate dihydrate is an antimalarial agent. It works by reducing oxygen intake and carbohydrate metabolism, disrupting DNA replication and transcription via DNA intercalation, and reducing excitability of muscle fibers via alteration of calcium distribution. It is also an inhibitor of P-glycoprotein.

Chemical Structure

Quinine sulfate dihydrate
Quinine sulfate dihydrate
CAS#6119-70-6 (sulfate dihydrate)

Theoretical Analysis

MedKoo Cat#: 561647

Name: Quinine sulfate dihydrate

CAS#: 6119-70-6 (sulfate dihydrate)

Chemical Formula: C40H54N4O10S

Exact Mass: 0.0000

Molecular Weight: 782.95

Elemental Analysis: C, 61.36; H, 6.95; N, 7.16; O, 20.43; S, 4.09

Price and Availability

Size Price Availability Quantity
5g USD 250.00 2 Weeks
25g USD 550.00 2 Weeks
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Synonym
Quinine sulfate dihydrate; Chinini sulfas; Quinine hemisulfate salt monohydrate;
IUPAC/Chemical Name
(1R)-(6-methoxyquinolin-4-yl)((2S,5R)-5-vinylquinuclidin-2-yl)methanol hemisulfate dihydrate
InChi Key
ZHNFLHYOFXQIOW-LRXYSQQVSA-N
InChi Code
InChI=1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14?,19-,20+;;;/m00.../s1
SMILES Code
COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3CC4CCN3C[C@@H]4C=C)O.COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3CC4CCN3C[C@@H]4C=C)O.O.O.OS(=O)(=O)O
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 782.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Würth C, Grabolle M, Pauli J, Spieles M, Resch-Genger U. Comparison of methods and achievable uncertainties for the relative and absolute measurement of photoluminescence quantum yields. Anal Chem. 2011 May 1;83(9):3431-9. doi: 10.1021/ac2000303. Epub 2011 Apr 7. PubMed PMID: 21473570. 2: Würth C, Lochmann C, Spieles M, Pauli J, Hoffmann K, Schüttrigkeit T, Franzl T, Resch-Genger U. Evaluation of a commercial integrating sphere setup for the determination of absolute photoluminescence quantum yields of dilute dye solutions. Appl Spectrosc. 2010 Jul;64(7):733-41. doi: 10.1366/000370210791666390. PubMed PMID: 20615286. 3: Mangwala Kimpende P, Van Meervelt L. Redetermination of bis-{(1S,2S,4S,5R)-2-[(R)-hy-droxy(6-meth-oxy-4-quinol-yl)meth-yl]-5-vinyl-quinuc lidinium} sulfate dihydrate. Acta Crystallogr Sect E Struct Rep Online. 2010 Aug 28;66(Pt 9):o2443-4. doi: 10.1107/S1600536810034288. PubMed PMID: 21588765; PubMed Central PMCID: PMC3008057. 4: Fluorescence standard reference material: quinine sulfate dihydrate. Appl Opt. 1981 May 1;20(9):1718. PubMed PMID: 20309374.