ABP700 | Anesthetic | CAS# 1446482-29-6

MedKoo Cat#: 571388 | Name: ABP-700

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ABP-700 is an etomidate analog that is effective as an anesthetic.

Chemical Structure

ABP-700

CAS#1446482-29-6 (free base)

Theoretical Analysis

MedKoo Cat#: 571388

Name: ABP-700

CAS#: 1446482-29-6 (free base)

Chemical Formula: C17H18N2O4

Exact Mass: 314.1267

Molecular Weight: 314.34

Elemental Analysis: C, 64.96; H, 5.77; N, 8.91; O, 20.36

Price and Availability

Size	Price	Availability
5mg	USD 150.00	Ready to Ship
10mg	USD 250.00	Ready to Ship
25mg	USD 550.00	Ready to Ship
50mg	USD 950.00	Ready to Ship
100mg	USD 1,650.00	Ready to Ship

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Related CAS #

1446482-29-6 (free base) ABP-700 HCl

Synonym

ABP700; ABP-700; ABP 700

IUPAC/Chemical Name

1H-Imidazole-5-carboxylic acid, 1-((1R)-1-phenylethyl)-, 1-(methoxycarbonyl)cyclopropyl ester

InChi Key

DRAFVCKNYNQOKR-GFCCVEGCSA-N

InChi Code

InChI=1S/C17H18N2O4/c1-12(13-6-4-3-5-7-13)19-11-18-10-14(19)15(20)23-17(8-9-17)16(21)22-2/h3-7,10-12H,8-9H2,1-2H3/t12-/m1/s1

SMILES Code

O=C(C1=CN=CN1[C@@H](C2=CC=CC=C2)C)OC3(C(OC)=O)CC3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#Y22X10M06

QC Data

View QC data: current batch, Lot#Y22X10M06

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

ABP-700 is an etomidate analog that is effective as an anesthetic.

In vitro activity:

TBD

In vivo activity:

High dose ABP-700 infusions produce involuntary muscle movements and seizures in Beagle dogs via distinct mechanisms. Reference: Anesthesiology. 2019 Aug;131(2):287-304. https://pubmed.ncbi.nlm.nih.gov/31166238/

Preparing Stock Solutions

The following data is based on the product molecular weight 314.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Valk BI, McGrath M, Lehoux D, Zerler B, Marota JJA, Raines DE. Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid. Anesthesiology. 2019 Aug;131(2):287-304. doi: 10.1097/ALN.0000000000002758. PMID: 31166238. 2. Campagna JA, Pojasek K, Grayzel D, Randle J, Raines DE. Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl-methoxycarbonyl metomidate in dogs. Anesthesiology. 2014 Dec;121(6):1203-16. doi: 10.1097/ALN.0000000000000416. PMID: 25170571; PMCID: PMC4237671.

In vitro protocol:

TBD

In vivo protocol:

1: Valk BI, McGrath M, Lehoux D, Zerler B, Marota JJA, Raines DE. Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid. Anesthesiology. 2019 Aug;131(2):287-304. doi: 10.1097/ALN.0000000000002758. PMID: 31166238. 2: Valk BI, Absalom AR, Meyer P, Meier S, den Daas I, van Amsterdam K, Campagna JA, Sweeney SP, Struys MMRF. Safety and clinical effect of i.v. infusion of cyclopropyl-methoxycarbonyl etomidate (ABP-700), a soft analogue of etomidate, in healthy subjects. Br J Anaesth. 2018 Jun;120(6):1401-1411. doi: 10.1016/j.bja.2018.01.038. Epub 2018 Mar 28. PMID: 29793605. 3: Struys MMRF, Valk BI, Eleveld DJ, Absalom AR, Meyer P, Meier S, den Daas I, Chou T, van Amsterdam K, Campagna JA, Sweeney SP. A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics-Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose. Anesthesiology. 2017 Jul;127(1):20-35. doi: 10.1097/ALN.0000000000001662. PMID: 28459733. 4: Valk BI, Eleveld DJ, Meyer P, Meier S, den Daas I, van Amsterdam K, Campagna JA, Sweeney SP, Absalom AR, Struys MMRF. Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700. Anesthesiology. 2021 Jan 1;134(1):35-51. doi: 10.1097/ALN.0000000000003590. Erratum in: Anesthesiology. 2021 Jan 1;134(1):138. PMID: 33064833. 5: Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700: Erratum. Anesthesiology. 2021 Jan 1;134(1):138. doi: 10.1097/ALN.0000000000003618. Erratum for: Anesthesiology. 2021 Jan 1;134(1):35-51. PMID: 33137179. 6: Valk BI, Struys MMRF. Etomidate and its Analogs: A Review of Pharmacokinetics and Pharmacodynamics. Clin Pharmacokinet. 2021 Jun 1. doi: 10.1007/s40262-021-01038-6. Epub ahead of print. PMID: 34060021. 7: Tejera E, Munteanu CR, López-Cortés A, Cabrera-Andrade A, Pérez-Castillo Y. Drugs Repurposing Using QSAR, Docking and Molecular Dynamics for Possible Inhibitors of the SARS-CoV-2 Mpro Protease. Molecules. 2020 Nov 6;25(21):5172. doi: 10.3390/molecules25215172. PMID: 33172092; PMCID: PMC7664330. 8: Campagna JA, Pojasek K, Grayzel D, Randle J, Raines DE. Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl- methoxycarbonyl metomidate in dogs. Anesthesiology. 2014 Dec;121(6):1203-16. doi: 10.1097/ALN.0000000000000416. PMID: 25170571; PMCID: PMC4237671.