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MedKoo Cat#: 527103 | Name: ABP-700 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ABP-700 is a novel, positive allosteric modulator of the GABAA receptor currently being developed for the induction of general anesthesia and procedural sedation. ABP-700 shows the expected suppressive effects for BIS and MOAA/S. .

Chemical Structure

ABP-700 HCl
ABP-700 HCl
CAS#ABP-700 HCl

Theoretical Analysis

MedKoo Cat#: 527103

Name: ABP-700 HCl

CAS#: ABP-700 HCl

Chemical Formula: C17H19ClN2O4

Exact Mass: 0.0000

Molecular Weight: 350.80

Elemental Analysis: C, 58.21; H, 5.46; Cl, 10.11; N, 7.99; O, 18.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
1446482-29-6 (free base) ABP-700 HCl
Synonym
ABP-700 HCl; ABP-700 hydrochloride; ABP-700; ABP 700; ABP700; CPMM;
IUPAC/Chemical Name
1-(methoxycarbonyl)cyclopropyl (R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylate hydrochloride
InChi Key
JUXJYXKBJBBWBK-UTONKHPSSA-N
InChi Code
InChI=1S/C17H18N2O4.ClH/c1-12(13-6-4-3-5-7-13)19-11-18-10-14(19)15(20)23-17(8-9-17)16(21)22-2;/h3-7,10-12H,8-9H2,1-2H3;1H/t12-;/m1./s1
SMILES Code
O=C(C1=CN=CN1[C@@H](C2=CC=CC=C2)C)OC3(C(OC)=O)CC3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 350.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Valk BI, McGrath M, Lehoux D, Zerler B, Marota JJA, Raines DE. Toxicologic and Inhibitory Receptor Actions of the Etomidate Analog ABP-700 and Its Metabolite CPM-Acid. Anesthesiology. 2019 Aug;131(2):287-304. doi: 10.1097/ALN.0000000000002758. PMID: 31166238. 2: Valk BI, Absalom AR, Meyer P, Meier S, den Daas I, van Amsterdam K, Campagna JA, Sweeney SP, Struys MMRF. Safety and clinical effect of i.v. infusion of cyclopropyl-methoxycarbonyl etomidate (ABP-700), a soft analogue of etomidate, in healthy subjects. Br J Anaesth. 2018 Jun;120(6):1401-1411. doi: 10.1016/j.bja.2018.01.038. Epub 2018 Mar 28. PMID: 29793605. 3: Struys MMRF, Valk BI, Eleveld DJ, Absalom AR, Meyer P, Meier S, den Daas I, Chou T, van Amsterdam K, Campagna JA, Sweeney SP. A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics-Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose. Anesthesiology. 2017 Jul;127(1):20-35. doi: 10.1097/ALN.0000000000001662. PMID: 28459733. 4: Valk BI, Eleveld DJ, Meyer P, Meier S, den Daas I, van Amsterdam K, Campagna JA, Sweeney SP, Absalom AR, Struys MMRF. Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700. Anesthesiology. 2021 Jan 1;134(1):35-51. doi: 10.1097/ALN.0000000000003590. Erratum in: Anesthesiology. 2021 Jan 1;134(1):138. PMID: 33064833. 5: Modeling the Effect of Excitation on Depth of Anesthesia Monitoring in γ-Aminobutyric Acid Type A Receptor Agonist ABP-700: Erratum. Anesthesiology. 2021 Jan 1;134(1):138. doi: 10.1097/ALN.0000000000003618. Erratum for: Anesthesiology. 2021 Jan 1;134(1):35-51. PMID: 33137179. 6: Valk BI, Struys MMRF. Etomidate and its Analogs: A Review of Pharmacokinetics and Pharmacodynamics. Clin Pharmacokinet. 2021 Jun 1. doi: 10.1007/s40262-021-01038-6. Epub ahead of print. PMID: 34060021. 7: Tejera E, Munteanu CR, López-Cortés A, Cabrera-Andrade A, Pérez-Castillo Y. Drugs Repurposing Using QSAR, Docking and Molecular Dynamics for Possible Inhibitors of the SARS-CoV-2 Mpro Protease. Molecules. 2020 Nov 6;25(21):5172. doi: 10.3390/molecules25215172. PMID: 33172092; PMCID: PMC7664330. 8: Campagna JA, Pojasek K, Grayzel D, Randle J, Raines DE. Advancing novel anesthetics: pharmacodynamic and pharmacokinetic studies of cyclopropyl- methoxycarbonyl metomidate in dogs. Anesthesiology. 2014 Dec;121(6):1203-16. doi: 10.1097/ALN.0000000000000416. PMID: 25170571; PMCID: PMC4237671.