Synonym
Setastine; Loderix;
IUPAC/Chemical Name
1-[2-[1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]azepane
InChi Key
VBSPHZOBAOWFCL-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H28ClNO/c1-22(19-9-5-4-6-10-19,20-11-13-21(23)14-12-20)25-18-17-24-15-7-2-3-8-16-24/h4-6,9-14H,2-3,7-8,15-18H2,1H3
SMILES Code
CC(C1=CC=CC=C1)(C2=CC=C(Cl)C=C2)OCCN3CCCCCC3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
357.92
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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7: Hirschberg A, Ribári O, Krasznai M. Results obtained with Loderix tablet in chronic rhinitis patients. Ther Hung. 1989;37(4):202-4. PubMed PMID: 2576575.
8: Németh A, Huszti Z. The effect of a new antihistamine drug, Loderix (EGIS-2062), on stimulus-evoked histamine release from rat peritoneal mast cells. Agents Actions. 1988 Apr;23(3-4):194-7. PubMed PMID: 2455987.
9: Vezekényi Z, Zolnai K, Nagy L. Comparative two-phase clinicopharmacological trial of a new antihistaminic, EGYT-2062, setastine. Acta Med Hung. 1987;44(1):55-64. PubMed PMID: 2890137.
