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MedKoo Cat#: 129085 | Name: NIBR-LTSi

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NIBR-LTSi is a highly selective, cellular active LATS kinase inhibitor. NIBR-LTSi showed attractive ADME/oral mouse PK properties and demonstrated dose-dependent target engagement as well as an increased expression of the YAP target gene Ctgf in murine liver.

Chemical Structure

NIBR-LTSi
NIBR-LTSi
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 129085

Name: NIBR-LTSi

CAS#: N/A

Chemical Formula: C18H20N4O

Exact Mass: 308.1637

Molecular Weight: 308.39

Elemental Analysis: C, 70.11; H, 6.54; N, 18.17; O, 5.19

Price and Availability

Related CAS #
No Data
Synonym
NIBR-LTSi; NIBR LTSi; NIBRLTSi
IUPAC/Chemical Name
(R)-N-(4-(piperidin-3-yloxy)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-amine
InChi Key
IYFCFYWXRIVCTH-OAHLLOKOSA-N
InChi Code
InChI=1S/C18H20N4O/c1-2-15(12-19-9-1)23-14-5-3-13(4-6-14)22-17-8-11-21-18-16(17)7-10-20-18/h3-8,10-11,15,19H,1-2,9,12H2,(H2,20,21,22)/t15-/m1/s1
SMILES Code
C1C[C@H](CNC1)OC2=CC=C(C=C2)NC3=C4C=CNC4=NC=C3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 308.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

1: Namoto K, Baader C, Orsini V, Landshammer A, Breuer E, Dinh KT, Ungricht R,

Pikiolek M, Laurent S, Lu B, Aebi A, Schönberger K, Vangrevelinghe E, Evrova O,

Sun T, Annunziato S, Lachal J, Redmond E, Wang L, Wetzel K, Capodieci P, Turner

J, Schutzius G, Unterreiner V, Trunzer M, Buschmann N, Behnke D, Machauer R,

Scheufler C, Parker CN, Ferro M, Grevot A, Beyerbach A, Lu WY, Forbes SJ, Wagner

J, Bouwmeester T, Liu J, Sohal B, Sahambi S, Greenbaum LE, Lohmann F, Hoppe P,

Cong F, Sailer AW, Ruffner H, Glatthar R, Humar B, Clavien PA, Dill MT, George

E, Maibaum J, Liberali P, Tchorz JS. NIBR-LTSi is a selective LATS kinase

inhibitor activating YAP signaling and expanding tissue stem cells in vitro and

in vivo. Cell Stem Cell. 2024 Apr 4;31(4):554-569.e17. doi:

10.1016/j.stem.2024.03.003. PMID: 38579685.

 

2: Jia L, Xiao H, Hao Z, Sun S, Zhao W, Gong Z, Gu W, Wen Y. Senolytic

elimination of senescent cells improved periodontal ligament stem cell-based

bone regeneration partially through inhibiting YAP. Biochim Biophys Acta Mol

Cell Res. 2025 Mar;1872(3):119921. doi: 10.1016/j.bbamcr.2025.119921. Epub 2025

Feb 17. PMID: 39971252.