MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 562745 | Name: SP-141
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SP-141 is a MDM2 inhibitor. It acts by exerting excellent in-vitro and in-vivo anticancer activity.

Chemical Structure

SP-141
SP-141
CAS#1253491-42-7

Theoretical Analysis

MedKoo Cat#: 562745

Name: SP-141

CAS#: 1253491-42-7

Chemical Formula: C22H16N2O

Exact Mass: 324.1263

Molecular Weight: 324.38

Elemental Analysis: C, 81.46; H, 4.97; N, 8.64; O, 4.93

Price and Availability

Size Price Availability Quantity
5mg USD 400.00 2 weeks
10mg USD 600.00 2 weeks
25mg USD 900.00 2 weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
SP-141; SP 141; SP141;
IUPAC/Chemical Name
6-Methoxy-1-naphthalen-1-yl-9H-pyrido[3,4-b]indole
InChi Key
AABFWJDLCCDJJN-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H16N2O/c1-25-15-9-10-20-19(13-15)18-11-12-23-21(22(18)24-20)17-8-4-6-14-5-2-3-7-16(14)17/h2-13,24H,1H3
SMILES Code
COC1=CC2=C(NC3=C2C=CN=C3C4=C5C=CC=CC5=CC=C4)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO and ethanol
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SP-141 is a high affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. SP-141 inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation.
In vitro activity:
SP-141 has potential as a therapeutic agent for pancreatic cancer. SP-141 reduced levels of MDM2 in pancreatic cancer cell lines, as well as their proliferation, with 50% inhibitory concentrations <0.5 μM (0.38-0.50 μM). Increasing concentrations of SP-141 induced increasing levels of apoptosis and G2-M-phase arrest of pancreatic cancer cell lines, whether or not they expressed functional P53. Reference: Gastroenterology. 2014 Oct;147(4):893-902.e2. https://pubmed.ncbi.nlm.nih.gov/25016295/
In vivo activity:
SP-141 is a novel targeted therapeutic agent that may especially benefit patients with advanced disease. SP-141 has strong in vivo antibreast cancer activity, with no apparent host toxicity. Reference: Nat Commun. 2014 Oct 1;5:5086. https://pubmed.ncbi.nlm.nih.gov/25271708/
Solvent mg/mL mM comments
Solubility
DMSO 32.4 100.00
Ethanol 32.4 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 324.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Wang W, Qin JJ, Voruganti S, Wang MH, Sharma H, Patil S, Zhou J, Wang H, Mukhopadhyay D, Buolamwini JK, Zhang R. Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice. Gastroenterology. 2014 Oct;147(4):893-902.e2. doi: 10.1053/j.gastro.2014.07.001. Epub 2014 Jul 10. PMID: 25016295; PMCID: PMC4170027. 2. Wang W, Qin JJ, Voruganti S, Srivenugopal KS, Nag S, Patil S, Sharma H, Wang MH, Wang H, Buolamwini JK, Zhang R. The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat Commun. 2014 Oct 1;5:5086. doi: 10.1038/ncomms6086. PMID: 25271708; PMCID: PMC6774205.
In vitro protocol:
1. Wang W, Qin JJ, Voruganti S, Wang MH, Sharma H, Patil S, Zhou J, Wang H, Mukhopadhyay D, Buolamwini JK, Zhang R. Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice. Gastroenterology. 2014 Oct;147(4):893-902.e2. doi: 10.1053/j.gastro.2014.07.001. Epub 2014 Jul 10. PMID: 25016295; PMCID: PMC4170027.
In vivo protocol:
1. Wang W, Qin JJ, Voruganti S, Srivenugopal KS, Nag S, Patil S, Sharma H, Wang MH, Wang H, Buolamwini JK, Zhang R. The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat Commun. 2014 Oct 1;5:5086. doi: 10.1038/ncomms6086. PMID: 25271708; PMCID: PMC6774205.
1: Nag S, Qin JJ, Patil S, Deokar H, Buolamwini JK, Wang W, Zhang R. A quantitative LC-MS/MS method for determination of SP-141, a novel pyrido[b]indole anticancer agent, and its application to a mouse PK study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Oct 15;969:235-240. doi: 10.1016/j.jchromb.2014.08.030. Epub 2014 Aug 28. PMID: 25195025; PMCID: PMC4201501. 2: Wang W, Qin JJ, Voruganti S, Srivenugopal KS, Nag S, Patil S, Sharma H, Wang MH, Wang H, Buolamwini JK, Zhang R. The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat Commun. 2014 Oct 1;5:5086. doi: 10.1038/ncomms6086. PMID: 25271708; PMCID: PMC6774205. 3: Nag S, Qin JJ, Voruganti S, Wang MH, Sharma H, Patil S, Buolamwini JK, Wang W, Zhang R. Development and validation of a rapid HPLC method for quantitation of SP-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice. Biomed Chromatogr. 2015 May;29(5):654-63. doi: 10.1002/bmc.3327. Epub 2014 Oct 8. PMID: 25294254; PMCID: PMC4710169. 4: Casini S, Caliani I, Giannetti M, Marsili L, Maltese S, Coppola D, Bianchi N, Campani T, Ancora S, Caruso C, Furii G, Parga M, D'Agostino A, Fossi MC. First ecotoxicological assessment of Caretta caretta (Linnaeus, 1758) in the Mediterranean Sea using an integrated nondestructive protocol. Sci Total Environ. 2018 Aug 1;631-632:1221-1233. doi: 10.1016/j.scitotenv.2018.03.111. Epub 2018 Mar 16. PMID: 29727947. 5: Marangi M, Carlino P, Profico C, Olivieri V, Totaro G, Furii G, Marzano G, Papini RA. First multicenter coprological survey on helminth parasite communities of free-living loggerhead sea turtles Caretta caretta (Linnaeus, 1758) from the Adriatic Sea and Northern Ionian Sea. Int J Parasitol Parasites Wildl. 2020 Feb 21;11:207-212. doi: 10.1016/j.ijppaw.2020.02.006. PMID: 32154102; PMCID: PMC7052436. 6: Punganuru SR, Artula V, Zhao W, Rajaei M, Deokar H, Zhang R, Buolamwini JK, Srivenugopal KS, Wang W. Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action. Cells. 2020 Jul 1;9(7):1592. doi: 10.3390/cells9071592. PMID: 32630235; PMCID: PMC7408354. 7: Valizadeh Rad K, Motesharezadeh B, Alikhani HA, Dadrasnia A. The potential use of Cordia myxa in the remediation of crude oil pollution. Int J Phytoremediation. 2021;23(5):445-453. doi: 10.1080/15226514.2020.1825326. Epub 2020 Oct 5. PMID: 33016103. 8: Narasimhan M, Mahimainathan L, Araj E, Clark AE, Wilkinson K, Yekkaluri S, Tiro J, Lee FM, Balani J, Sarode R, Singal AG, Muthukumar A. Expanding COVID-19 Vaccine Availability: Role for Combined Orthogonal Serology Testing (COST). Vaccines (Basel). 2021 Apr 13;9(4):376. doi: 10.3390/vaccines9040376. PMID: 33924340; PMCID: PMC8069830. 9: Chitneni SK, Zhou Z, Watts BE, Zalutsky MR. Feasibility of Developing Radiotracers for MDM2: Synthesis and Preliminary Evaluation of an 18F-Labeled Analogue of the MDM2 Inhibitor SP-141. Pharmaceuticals (Basel). 2021 Apr 13;14(4):358. doi: 10.3390/ph14040358. PMID: 33924734; PMCID: PMC8070256. 10: Wu XY, Dong B, Zhu XM, Cai YY, Li L, Lu JP, Yu B, Cheng JL, Xu F, Bao JD, Wang Y, Liu XH, Lin FC. SP-141 targets Trs85 to inhibit rice blast fungus infection and functions as a potential broad-spectrum antifungal agent. Plant Commun. 2024 Feb 12;5(2):100724. doi: 10.1016/j.xplc.2023.100724. Epub 2023 Sep 27. PMID: 37771153; PMCID: PMC10873891.