Synonym
Tazanolast; WP-833; WP 833; WP833;
IUPAC/Chemical Name
Butyl 2-oxo-2-[3-(2H-tetrazol-5-yl)anilino]acetate
InChi Key
XQTARQNQIVVBRX-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H15N5O3/c1-2-3-7-21-13(20)12(19)14-10-6-4-5-9(8-10)11-15-17-18-16-11/h4-6,8H,2-3,7H2,1H3,(H,14,19)(H,15,16,17,18)
SMILES Code
O=C(OCCCC)C(NC1=CC=CC(C2=NNN=N2)=C1)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
289.29
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Igarashi A, Iijima H, Tamura G, Shirato K. Tazanolast inhibits ozone-induced airway hyperresponsiveness in guinea pigs. Am J Respir Crit Care Med. 1998 May;157(5 Pt 1):1531-5. PubMed PMID: 9603134.
2: Kamei C, Mio M, Yoshida T, Saito Y, Toyoda Y, Tsuriya Y. Effect of an active metabolite of the antiallergic agent tazanolast on histamine release from rat mast cells. Arzneimittelforschung. 1997 Apr;47(4):390-4. PubMed PMID: 9150859.
3: Tominaga T, Watanbe A, Tsuji J, Koda A, Nagai H, Kumazawa Y, Shimada H. Effect of TYB-2285 on antigen-induced accumulation of eosinophils into the peritoneal cavity of rats sensitized with Ascaris suum extract. Gen Pharmacol. 1997 Mar;28(3):411-4. PubMed PMID: 9068982.
4: Nishizawa Y, Yamamoto T, Terada N, Fushiki S, Amakata Y, Nishizawa Y. Effects of antiallergic drugs on the proliferation of estrogen-sensitive mouse Leydig cell line. Anticancer Res. 1996 May-Jun;16(3A):1241-5. PubMed PMID: 8702244.
5: Hashimoto T, Toyoda Y, Matsukawa H, Tsuriya Y, Yanagihara Y. [Effect of tazanolast on platelet activating factor-induced airway hyperresponsiveness in guinea pigs]. Arerugi. 1992 Sep;41(9):1430-3. Japanese. PubMed PMID: 1280089.
6: Hashimoto T, Edanami K, Naito A, Sano K, Fushimi H, Goto M. [Anti-allergic effects of tazanolast [butyl 3'-(1H-tetrazol-5-yl) oxanilate, WP-833] metabolites]. Nihon Yakurigaku Zasshi. 1990 Apr;95(4):159-66. Japanese. PubMed PMID: 1695192.
