Synonym
Carbazomycin A; Carbazomycin-A;
IUPAC/Chemical Name
3,4-dimethoxy-1,2-dimethyl-9H-carbazole
InChi Key
CABZEVNLYSXBGW-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H17NO2/c1-9-10(2)15(18-3)16(19-4)13-11-7-5-6-8-12(11)17-14(9)13/h5-8,17H,1-4H3
SMILES Code
COC1=C(OC)C(C2=C(N3)C=CC=C2)=C3C(C)=C1C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
255.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Singh S, Samineni R, Pabbaraja S, Mehta G. A General Carbazole Synthesis via Stitching of Indole-Ynones with Nitromethanes: Application to Total Synthesis of Carbazomycin A, Calothrixin B, and Staurosporinone. Org Lett. 2019 May 3;21(9):3372-3376. doi: 10.1021/acs.orglett.9b01111. Epub 2019 Apr 23. PMID: 31013110.
2: Wu S, Harada S, Morikawa T, Nishida A. Total Synthesis of Carbazomycins A and B. Chem Pharm Bull (Tokyo). 2018;66(2):178-183. doi: 10.1248/cpb.c17-00851. PMID: 29386469.
3: Markad SB, Argade NP. Diversity oriented convergent access for collective total synthesis of bioactive multifunctional carbazole alkaloids: synthesis of carbazomycin A, carbazomycin B, hyellazole, chlorohyellazole, and clausenaline D. Org Lett. 2014 Oct 17;16(20):5470-3. doi: 10.1021/ol502721r. Epub 2014 Oct 9. PMID: 25296703.
4: Yamasaki K, Kaneda M, Watanabe K, Ueki Y, Ishimaru K, Nakamura S, Nomi R, Yoshida N, Nakajima T. New antibiotics, carbazomycins A and B. III. Taxonomy and biosynthesis. J Antibiot (Tokyo). 1983 May;36(5):552-8. doi: 10.7164/antibiotics.36.552. PMID: 6874571.
5: Sakano K, Nakamura S. New antibiotics, carbazomycins A and B. II. Structural elucidation. J Antibiot (Tokyo). 1980 Sep;33(9):961-6. doi: 10.7164/antibiotics.33.961. PMID: 7440417.
6: Sakano K, Ishimaru K, Nakamura S. New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties. J Antibiot (Tokyo). 1980 Jul;33(7):683-9. doi: 10.7164/antibiotics.33.683. PMID: 7410212.
