Sulfachlorpyridazine | CAS#80-32-0 | Antibacterial Agent

MedKoo Cat#: 584114 | Name: Sulfachlorpyridazine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sulfachlorpyridazine, also known as Sonilyn, Cluricol, Durasulf, and Ba 10370, is an antibacterial agent typically used in agricultural practices.

Chemical Structure

Sulfachlorpyridazine

CAS#80-32-0

Theoretical Analysis

MedKoo Cat#: 584114

Name: Sulfachlorpyridazine

CAS#: 80-32-0

Chemical Formula: C10H9ClN4O2S

Exact Mass: 284.0135

Molecular Weight: 284.71

Elemental Analysis: C, 42.19; H, 3.19; Cl, 12.45; N, 19.68; O, 11.24; S, 11.26

Price and Availability

Size	Price	Availability	Quantity
250mg	USD 200.00

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Synonym

Sulfachlorpyridazine; Sonilyn; Cluricol; Durasulf; Ba 10370; Ba-10370; Ba10370

IUPAC/Chemical Name

Benzenesulfonamide, 4-amino-N-(6-chloro-3-pyridazinyl)-

InChi Key

XOXHILFPRYWFOD-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)

SMILES Code

O=S(C1=CC=C(N)C=C1)(NC2=NN=C(Cl)C=C2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 284.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Tissue residue distribution and withdrawal time estimation of trimethoprim and sulfachloropyridazine in Yugan black-bone fowl (Gallus gallus domesticus Brisson). Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2023 Aug;40(8):981-991. doi: 10.1080/19440049.2023.2232884. Epub 2023 Jul 19. PMID: 37466973. 5: Gu YG, Gao YP, Jiang SJ, Jordan RW, Yang YF. Ecotoxicological risk of antibiotics and their mixtures to aquatic biota with the DGT technique in sediments. Ecotoxicology. 2023 May;32(4):536-543. doi: 10.1007/s10646-023-02656-5. Epub 2023 May 3. PMID: 37133692. 6: Yuan L, Wu H, Wang J, Zhou M, Zhang L, Xiang J, Liao Q, Luo L, Qian M, Zhang D. Pharmacokinetics, withdrawal time, and dietary risk assessment of enrofloxacin and its metabolite ciprofloxacin, and sulfachloropyridazine- trimethoprim in Taihe black-boned silky fowls. J Food Sci. 2023 Apr;88(4):1743-1752. doi: 10.1111/1750-3841.16501. Epub 2023 Feb 15. PMID: 36789868. 7: Hu J, Tang X, Qi M, Cheng J. New Models for Estimating the Sorption of Sulfonamide and Tetracycline Antibiotics in Soils. Int J Environ Res Public Health. 2022 Dec 14;19(24):16771. doi: 10.3390/ijerph192416771. PMID: 36554653; PMCID: PMC9778684. 8: Zahran SS, Ragab FA, El-Gazzar MG, Soliman AM, Mahmoud WR, Ghorab MM. Antiproliferative, antiangiogenic and apoptotic effect of new hybrids of quinazoline-4(3H)-ones and sulfachloropyridazine. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114912. doi: 10.1016/j.ejmech.2022.114912. Epub 2022 Nov 9. PMID: 36395650. 9: Li X, Jiang X, Qi D, Wang X, Wang C, Fei C, Zhou W, Li J, Zhang K. Effects of ethanamizuril, sulfachlorpyridazine or their combination on cecum microbial community and metabolomics in chickens infected with Eimeria tenella. Microb Pathog. 2022 Dec;173(Pt A):105823. doi: 10.1016/j.micpath.2022.105823. Epub 2022 Oct 12. PMID: 36243384. 10: Xu R, Yang C, Huang L, Lv W, Yang W, Wu Y, Fu F. Broad-Specificity Aptamer of Sulfonamides: Isolation and Its Application in Simultaneous Detection of Multiple Sulfonamides in Fish Sample. J Agric Food Chem. 2022 Sep 21;70(37):11804-11812. doi: 10.1021/acs.jafc.2c03423. Epub 2022 Sep 7. PMID: 36070569. 11: He Z, Wang Q, Rao P, Dong L, Zhang M, Zhang X, Gao N, Deng J. WS2 significantly enhances the degradation of sulfachloropyridazine by Fe(III)/persulfate. Sci Total Environ. 2022 Dec 1;850:157987. doi: 10.1016/j.scitotenv.2022.157987. Epub 2022 Aug 11. PMID: 35964753. 12: Yu D, He J, Xie T, Xu Q, Li G, Du L, Huang J, Yang J, Li W, Wang J. Peroxymonosulfate activation using a composite of copper and nickel oxide coated on SBA-15 for the removal of sulfonamide antibiotics. Environ Res. 2022 Apr 15;206:112301. doi: 10.1016/j.envres.2021.112301. Epub 2021 Oct 29. PMID: 34736639. 13: Liu L, Sim SF, Lin S, Wan J, Zhang W, Li Q, Peng C. Integrated structural and chemical analyses for HCl-supported hydrochar and their adsorption mechanisms for aqueous sulfachloropyridazine removal. J Hazard Mater. 2021 Sep 5;417:126009. doi: 10.1016/j.jhazmat.2021.126009. Epub 2021 May 7. PMID: 34229376. 14: Conde-Cid M, Cela-Dablanca R, Ferreira-Coelho G, Fernández-Calviño D, Núñez- Delgado A, Fernández-Sanjurjo MJ, Arias-Estévez M, Álvarez-Rodríguez E. Sulfadiazine, sulfamethazine and sulfachloropyridazine removal using three different porous materials: Pine bark, "oak ash" and mussel shell. Environ Res. 2021 Apr;195:110814. doi: 10.1016/j.envres.2021.110814. Epub 2021 Jan 30. PMID: 33524329. 15: Ma J, Zhang S, Duan X, Wang Y, Wu D, Pang J, Wang X, Wang S. Catalytic oxidation of sulfachloropyridazine by MnO2: Effects of crystalline phase and peroxide oxidants. Chemosphere. 2021 Mar;267:129287. doi: 10.1016/j.chemosphere.2020.129287. Epub 2020 Dec 11. PMID: 33348268. 16: Jiang X, Zhu Y, Liu L, Fan X, Bao Y, Deng S, Cui Y, Cagnetta G, Huang J, Yu G. Occurrence and variations of pharmaceuticals and personal-care products in rural water bodies: A case study of the Taige Canal (2018-2019). Sci Total Environ. 2021 Mar 25;762:143138. doi: 10.1016/j.scitotenv.2020.143138. Epub 2020 Oct 17. PMID: 33121774. 17: Zhou X, Wang J, Lu C, Liao Q, Gudda FO, Ling W. Antibiotics in animal manure and manure-based fertilizers: Occurrence and ecological risk assessment. Chemosphere. 2020 Sep;255:127006. doi: 10.1016/j.chemosphere.2020.127006. Epub 2020 May 8. PMID: 32417517. 18: Jansen LJM, Berentsen RJ, Arends M, Berendsen BJA. The vertical transmission of antibiotic residues from parent hens to broilers. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2020 May;37(5):783-792. doi: 10.1080/19440049.2020.1725147. Epub 2020 Feb 19. PMID: 32073357. 19: Conde-Cid M, Fernández-Calviño D, Fernández-Sanjurjo MJ, Núñez-Delgado A, Álvarez-Rodríguez E, Arias-Estévez M. Effects of pine bark amendment on the transport of sulfonamide antibiotics in soils. Chemosphere. 2020 Jun;248:126041. doi: 10.1016/j.chemosphere.2020.126041. Epub 2020 Jan 28. PMID: 32028162. 20: Conde-Cid M, Fernández-Calviño D, Fernández-Sanjurjo MJ, Núñez-Delgado A, Álvarez-Rodríguez E, Arias-Estévez M. Adsorption/desorption and transport of sulfadiazine, sulfachloropyridazine, and sulfamethazine, in acid agricultural soils. Chemosphere. 2019 Nov;234:978-986. doi: 10.1016/j.chemosphere.2019.06.121. Epub 2019 Jun 20. PMID: 31519107.