VU6010608 is a potent mGlu7 NAM. VU6010608 showed excellent CNS penetration (Kp 1.9−5.8 and Kp,uu 0.4−1.4). VU6010608 emerged with robust efficacy in blocking high frequency stimulated long-term potentiation in electrophysiology studies. VU6010608 displayed low predicted hepatic clearance in rat (CLhep = 9.5 mL/min/kg) and moderate in mouse (CLhep = 48.5 mL/min/kg).
MedKoo Cat#: 530983
Name: VU6010608
CAS#: Unknown
Chemical Formula: C18H15F3N4O4
Exact Mass: 408.1045
Molecular Weight: 408.34
Elemental Analysis: C, 52.95; H, 3.70; F, 13.96; N, 13.72; O, 15.67
The following data is based on the product molecular weight 408.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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