MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 407251 | Name: CYM-5442
Featured New

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CYM-5442 is a highly-selective S1P1 (Spingosine 1-Phosphate Receptor 1) agonist. CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment. CYM-5442 significantly inhibited but did not prevent aGVHD. CYM-5442 treatment downregulated CCL2 and CCL7 expression in endothelial cells, therefore reducing the migration of monocytes, from which tissue macrophages originate. CYM-5442 may be a potential therapeutic regimen for aGVHD.

Chemical Structure

CYM-5442
CYM-5442
CAS#1094042-01-9

Theoretical Analysis

MedKoo Cat#: 407251

Name: CYM-5442

CAS#: 1094042-01-9

Chemical Formula: C23H27N3O4

Exact Mass: 409.2002

Molecular Weight: 409.49

Elemental Analysis: C, 67.46; H, 6.65; N, 10.26; O, 15.63

Price and Availability

Size Price Availability Quantity
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 1,950.00 2 Weeks
500mg USD 2,450.00 2 Weeks
1g USD 3,450.00 2 Weeks
2g USD 5,950.00 2 Weeks
Show More
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
CYM-5442; CYM 5442; CYM5442.
IUPAC/Chemical Name
2-((4-(5-(3,4-diethoxyphenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl)amino)ethan-1-ol
InChi Key
NUIKTBLZSPQGCP-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H27N3O4/c1-3-28-20-11-8-15(14-21(20)29-4-2)23-25-22(26-30-23)18-7-5-6-17-16(18)9-10-19(17)24-12-13-27/h5-8,11,14,19,24,27H,3-4,9-10,12-13H2,1-2H3
SMILES Code
CCOC1=CC=C(C2=NC(C3=CC=CC4=C3CCC4NCCO)=NO2)C=C1OCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 409.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li C, Li JN, Kays J, Guerrero M, Nicol GD. Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. J Neuroinflammation. 2015 Apr 12;12:70. doi: 10.1186/s12974-015-0286-8. PubMed PMID: 25880547; PubMed Central PMCID: PMC4397880. 2: Cheng Q, Ma S, Lin D, Mei Y, Gong H, Lei L, Chen Y, Zhao Y, Hu B, Wu Y, Yu X, Zhao L, Liu H. The S1P1 receptor-selective agonist CYM-5442 reduces the severity of acute GVHD by inhibiting macrophage recruitment. Cell Mol Immunol. 2015 Nov;12(6):681-91. doi: 10.1038/cmi.2014.59. Epub 2014 Aug 4. PubMed PMID: 25088224. 3: Costes LM, van der Vliet J, Farro G, Matteoli G, van Bree SH, Olivier BJ, Nolte MA, Boeckxstaens GE, Cailotto C. The spleen responds to intestinal manipulation but does not participate in the inflammatory response in a mouse model of postoperative ileus. PLoS One. 2014 Jul 10;9(7):e102211. doi: 10.1371/journal.pone.0102211. eCollection 2014. PubMed PMID: 25010202; PubMed Central PMCID: PMC4092106. 4: Janes K, Little JW, Li C, Bryant L, Chen C, Chen Z, Kamocki K, Doyle T, Snider A, Esposito E, Cuzzocrea S, Bieberich E, Obeid L, Petrache I, Nicol G, Neumann WL, Salvemini D. The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1. J Biol Chem. 2014 Jul 25;289(30):21082-97. PubMed PMID: 24876379; PubMed Central PMCID: PMC4110312. 5: Parrill AL, Lima S, Spiegel S. Structure of the first sphingosine 1-phosphate receptor. Sci Signal. 2012 May 22;5(225):pe23. doi: 10.1126/scisignal.2003160. PubMed PMID: 22623751; PubMed Central PMCID: PMC3632326. 6: Riddy DM, Stamp C, Sykes DA, Charlton SJ, Dowling MR. Reassessment of the pharmacology of Sphingosine-1-phosphate S1P3 receptor ligands using the DiscoveRx PathHunter™ and Ca2+ release functional assays. Br J Pharmacol. 2012 Oct;167(4):868-80. doi: 10.1111/j.1476-5381.2012.02032.x. PubMed PMID: 22577868; PubMed Central PMCID: PMC3575785. 7: Poti F, Costa S, Bergonzini V, Galletti M, Pignatti E, Weber C, Simoni M, Nofer JR. Effect of sphingosine 1-phosphate (S1P) receptor agonists FTY720 and CYM5442 on atherosclerosis development in LDL receptor deficient (LDL-R⁻/⁻) mice. Vascul Pharmacol. 2012 Aug 19;57(1):56-64. doi: 10.1016/j.vph.2012.03.003. Epub 2012 Mar 20. PubMed PMID: 22459073. 8: Gonzalez-Cabrera PJ, Cahalan SM, Nguyen N, Sarkisyan G, Leaf NB, Cameron MD, Kago T, Rosen H. S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis. Mol Pharmacol. 2012 Feb;81(2):166-74. doi: 10.1124/mol.111.076109. Epub 2011 Oct 26. PubMed PMID: 22031473; PubMed Central PMCID: PMC3263953. 9: Schröder M, Richter C, Juan MH, Maltusch K, Giegold O, Quintini G, Pfeilschifter JM, Huwiler A, Radeke HH. The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen. Mol Immunol. 2011 May;48(9-10):1139-48. doi: 10.1016/j.molimm.2011.02.007. Epub 2011 Mar 23. PubMed PMID: 21435724. 10: Gonzalez-Cabrera PJ, Jo E, Sanna MG, Brown S, Leaf N, Marsolais D, Schaeffer MT, Chapman J, Cameron M, Guerrero M, Roberts E, Rosen H. Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol Pharmacol. 2008 Nov;74(5):1308-18. doi: 10.1124/mol.108.049783. Epub 2008 Aug 15. PubMed PMID: 18708635; PubMed Central PMCID: PMC2575047.

View History

Vapitadine

Vapitadine