Thifluzamide | CAS#130000-40-7 | SDHI

MedKoo Cat#: 561570 | Name: Thifluzamide

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thifluzamide is a succinate dehydrogenase inhibitor (SDHI) with strong antifungal activity.

Chemical Structure

Thifluzamide

CAS#130000-40-7

Theoretical Analysis

MedKoo Cat#: 561570

Name: Thifluzamide

CAS#: 130000-40-7

Chemical Formula: C13H6Br2F6N2O2S

Exact Mass: 525.8421

Molecular Weight: 528.06

Elemental Analysis: C, 29.57; H, 1.15; Br, 30.26; F, 21.59; N, 5.31; O, 6.06; S, 6.07

Price and Availability

Size	Price	Availability	Quantity
250mg	USD 280.00

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Thifluzamide;

IUPAC/Chemical Name

N-(2,6-Dibromo-4-(trifluoromethoxy)phenyl)-2-methyl-4-(trifluoromethyl)thiazole-5-carboxamide

InChi Key

WOSNCVAPUOFXEH-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H6Br2F6N2O2S/c1-4-22-10(12(16,17)18)9(26-4)11(24)23-8-6(14)2-5(3-7(8)15)25-13(19,20)21/h2-3H,1H3,(H,23,24)

SMILES Code

O=C(C1=C(C(F)(F)F)N=C(C)S1)NC2=C(Br)C=C(OC(F)(F)F)C=C2Br

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 528.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jiang C, Zhou L, Wang M, Shen S, Cheng W, Zhao Q, Cui K, He L. Sensitivity determination and resistance mechanism of Sclerotium rolfsii to difenoconazole. Pest Manag Sci. 2024 Dec 26. doi: 10.1002/ps.8624. Epub ahead of print. PMID: 39726070. 2: Wu Y, Yan W, Sun X, Zhang X, Ge Y, Jia X. Effects of Thifluzamide Treatment on the Production of Cell Wall Degrading Enzymes in Rhizoctonia solani and Phenylpropane Metabolism in Pear Fruit. Pathogens. 2024 Nov 5;13(11):963. doi: 10.3390/pathogens13110963. PMID: 39599516; PMCID: PMC11597378. 3: Xu XY, Duan MM, Zhou JY, Li YB, Zheng YQ, Yang Y. A systematic workflow of data mining confirms widespread ecological risks of SDHIs fungicides contamination in aquatic environment. Sci Total Environ. 2024 Dec 20;957:177538. doi: 10.1016/j.scitotenv.2024.177538. Epub 2024 Nov 18. PMID: 39542269. 4: Liu M, Liu T, Yang Y, Li Q, Mao H, Li X, Wang F, Zhao J, Wu Y, Zhang C. Comparison of rDNA-ITS Sequences, Vegetative Compatibility, Biological Characteristics, and Thifluzamide Sensitivity of Rhizoctonia solani AG-3 PT, TM, and TB Subgroup Isolates Collected from Potato and Tobacco in China. Plant Dis. 2024 Nov 11. doi: 10.1094/PDIS-07-24-1407-RE. Epub ahead of print. PMID: 39529429. 5: Wang Y, Wan Y, Li S, He Z, Xu S, Xia W. Occurrence, spatial variation, seasonal difference, and risk assessment of neonicotinoid insecticides, selected agriculture fungicides, and their transformation products in the Yangtze River, China: From the upper to lower reaches. Water Res. 2023 Oct 9;247:120724. doi: 10.1016/j.watres.2023.120724. Epub ahead of print. PMID: 39492000. 6: Yadav S, Sewariya S, Raman APS, Arun, Singh P, Chandra R, Jain P, Singh A, Kumari K. A multifaceted approach to investigate interactions of thifluzamide with haemoglobin. Int J Biol Macromol. 2024 Dec;282(Pt 2):136736. doi: 10.1016/j.ijbiomac.2024.136736. Epub 2024 Oct 19. PMID: 39433183. 7: Ou M, Hu K, Li M, Liu S, Zhang X, Lu X, Zhan X, Liao X, Li M, Li R. Resistance risk assessment of Rhizoctonia solani to four fungicides. Pest Manag Sci. 2025 Feb;81(2):867-883. doi: 10.1002/ps.8490. Epub 2024 Oct 19. PMID: 39425558. 8: Yin YM, Zhang XM, Shang XY, Gao ZH, Liang ZB, Wang DW, Xi Z. Discovery of Benzothiazol-2-ylthiophenylpyrazole-4-carboxamides as Novel Succinate Dehydrogenase Inhibitors. J Agric Food Chem. 2024 Aug 14;72(32):17802-17812. doi: 10.1021/acs.jafc.4c01739. Epub 2024 Aug 2. PMID: 39092526. 9: Ren XX, Chen L, Yu-Chi, Zhao-Li, Su XY, Shun-He, Ye ZH. Development and application of a novel suspension concentrate for seed coating of rice for controlling bakanae disease and seedling rot disease. Front Bioeng Biotechnol. 2024 Jun 6;12:1418313. doi: 10.3389/fbioe.2024.1418313. PMID: 38903191; PMCID: PMC11187768. 10: Chaoxi W, Yubin C, Yunfu C, Lujiang X, Wei Q. Understanding dilution effects on particle-containing pesticide droplets deposition on rice leaf via developing CFD-VOF-DPM model. Pest Manag Sci. 2024 Sep;80(9):4725-4735. doi: 10.1002/ps.8188. Epub 2024 May 28. PMID: 38804696. 11: Chen X, Jiang Y, Wang C, Yue L, Li X, Cao X, White JC, Wang Z, Xing B. Selenium Nanomaterials Enhance Sheath Blight Resistance and Nutritional Quality of Rice: Mechanisms of Action and Human Health Benefit. ACS Nano. 2024 May 21;18(20):13084-13097. doi: 10.1021/acsnano.4c01835. Epub 2024 May 10. PMID: 38727520. 12: Kim M, Cho M, Kim SH, Lee Y, Jo MR, Moon YS, Im MH. Monitoring and Risk Assessment of Pesticide Residues in Fishery Products Using GC-MS/MS in South Korea. Toxics. 2024 Apr 18;12(4):299. doi: 10.3390/toxics12040299. PMID: 38668522; PMCID: PMC11053634. 13: Gan W, Zhang R, Cao Z, Liu H, Fan W, Sun A, Song S, Zhang Z, Shi X. Unveiling the hidden risks: Pesticide residues in aquaculture systems. Sci Total Environ. 2024 Jun 15;929:172388. doi: 10.1016/j.scitotenv.2024.172388. Epub 2024 Apr 16. PMID: 38614356. 14: Xu Z, Cheng X, Cui H, Cao L, Song Y, Chang X, Wang D, Lv X. Design, selective synthesis and biological activities evaluation of novel thiazol-2-ylbenzamide and thiazole-2-ylbenzimidoyl chloride derivatives. Bioorg Chem. 2024 Jun;147:107333. doi: 10.1016/j.bioorg.2024.107333. Epub 2024 Apr 6. PMID: 38599055. 15: Song D, Wen R, Chen K, Wen F, Xing D, Wu Z. Application of thifluzamide to stem rot in peppers: Infection and control mechanisms of sclerotium rolfsii. Pestic Biochem Physiol. 2024 Mar;200:105846. doi: 10.1016/j.pestbp.2024.105846. Epub 2024 Mar 2. PMID: 38582578. 16: Song J, Qiu H, Meng X, Li S, Mao Y, Zhang L, Cai Y, Wang J, Zhou M, Duan Y. Risk assessment and molecular mechanism of Sclerotium rolfsii resistance to boscalid. Pestic Biochem Physiol. 2024 Mar;200:105806. doi: 10.1016/j.pestbp.2024.105806. Epub 2024 Feb 1. PMID: 38582572. 17: Kerhoas M, Carteret J, Huchet L, Jouan E, Huc L, Vée ML, Fardel O. Induction of human hepatic cytochrome P-450 3A4 expression by antifungal succinate dehydrogenase inhibitors. Ecotoxicol Environ Saf. 2024 May;276:116261. doi: 10.1016/j.ecoenv.2024.116261. Epub 2024 Apr 3. PMID: 38574644. 18: Cui K, Jiang C, Sun L, Wang M, He L, Zhou L. Resistance risk assessment for benzovindiflupyr in Sclerotium rolfsii and transmission of resistance genes among population. Pest Manag Sci. 2024 Aug;80(8):3979-3987. doi: 10.1002/ps.8101. Epub 2024 Apr 5. PMID: 38520375. 19: Cui K, Ma G, Zhao S, Guan S, Liang J, Fang L, Ding R, Li T, Hao Q, Dong Z, Wang J. Dissipation, accumulation, distribution and risk assessment of fungicides in greenhouse and open-field cowpeas. Food Chem X. 2024 Feb 6;21:101172. doi: 10.1016/j.fochx.2024.101172. PMID: 38379796; PMCID: PMC10877180. 20: Wang M, Li G, Zhou L, Hao Y, Wang L, Mao X, Zhang G, Zhao C. Design, synthesis and bioactivity of a new class of antifungal amino acid-directed phthalide compounds. Pest Manag Sci. 2024 Jul;80(7):3182-3193. doi: 10.1002/ps.8028. Epub 2024 Feb 28. PMID: 38358013.