KSK-120 | CAS#1638100-63-6 | Chlamydia trachomatis

MedKoo Cat#: 530981 | Name: KSK-120

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KSK-120 is a potent Chlamydia trachomatis inhibitor that targets the glucose metabolism pathway of Chlamydia trachomatis. KSK120 targets the glucose-6-phosphate (G-6P) metabolism pathway of C. trachomatis, supporting previous indications that G-6P metabolism is critical for C. trachomatis infectivity. Thus, KSK120 may be a useful tool to study chlamydial glucose metabolism and has the potential to be used in the treatment of C. trachomatis infections.

Chemical Structure

KSK-120

CAS#1638100-63-6

Theoretical Analysis

MedKoo Cat#: 530981

Name: KSK-120

CAS#: 1638100-63-6

Chemical Formula: C28H22N2O2S

Exact Mass: 450.1402

Molecular Weight: 450.56

Elemental Analysis: C, 74.64; H, 4.92; N, 6.22; O, 7.10; S, 7.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

KSK-120; KSK 120; KSK120.

IUPAC/Chemical Name

8-cyclopropyl-7-(naphthalen-1-ylmethyl)-5-oxo-N-phenyl-5H-thiazolo[3,2-a]pyridine-3-carboxamide

InChi Key

TYPJPKPPPMYZMM-UHFFFAOYSA-N

InChi Code

InChI=1S/C28H22N2O2S/c31-25-16-21(15-20-9-6-8-18-7-4-5-12-23(18)20)26(19-13-14-19)28-30(25)24(17-33-28)27(32)29-22-10-2-1-3-11-22/h1-12,16-17,19H,13-15H2,(H,29,32)

SMILES Code

O=C(N(C(C(NC1=CC=CC=C1)=O)=CS2)C2=C3C4CC4)C=C3CC5=CC=CC6=C5C=CC=C6

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Chlamydia trachomatis is a bacterial pathogen of humans that causes a common sexually transmitted disease as well as eye infections. It grows only inside cells of its host organism, within a parasitophorous vacuole termed the inclusion. Little is known, however, about what bacterial components and processes are important for C. trachomatis cellular infectivity.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 450.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Engström P, Bergström M, Alfaro AC, Syam Krishnan K, Bahnan W, Almqvist F, Bergström S. Expansion of the Chlamydia trachomatis inclusion does not require bacterial replication. Int J Med Microbiol. 2015 May;305(3):378-82. doi: 10.1016/j.ijmm.2015.02.007. Epub 2015 Feb 27. PubMed PMID: 25771502. 2: Engström P, Krishnan KS, Ngyuen BD, Chorell E, Normark J, Silver J, Bastidas RJ, Welch MD, Hultgren SJ, Wolf-Watz H, Valdivia RH, Almqvist F, Bergström S. A 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis. MBio. 2014 Dec 30;6(1):e02304-14. doi: 10.1128/mBio.02304-14. PubMed PMID: 25550323; PubMed Central PMCID: PMC4281921.