ICI-170777 | CAS# 123297-52-9 | Biochemical

MedKoo Cat#: 576499 | Name: ICI-170777

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ICI-170777 is a vasodilator with positive inotropic effects

Chemical Structure

ICI-170777

CAS#123297-52-9

Theoretical Analysis

MedKoo Cat#: 576499

Name: ICI-170777

CAS#: 123297-52-9

Chemical Formula: C9H9N3OS

Exact Mass: 207.0466

Molecular Weight: 207.25

Elemental Analysis: C, 52.16; H, 4.38; N, 20.28; O, 7.72; S, 15.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

ICI 170777; ICI170777; ICI-170777

IUPAC/Chemical Name

2H-1,3,4-Thiadiazin-2-one, 3,6-dihydro-6-methyl-5-(4-pyridinyl)-, (+-)-

InChi Key

PXZLHVGFLSUUIW-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H9N3OS/c1-6-8(11-12-9(13)14-6)7-2-4-10-5-3-7/h2-6H,1H3,(H,12,13)

SMILES Code

CC1SC(=O)NN=C1c2ccncc2

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 207.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Collis MG, Keddie JR, Rouse W. The cardiovascular pharmacology of ICI 170777 ((6RS)-6-methyl-5-(pyrid-4-yl)-3H,6H-1,3,4- thiadiazin-2-one) a novel compound with positive inotropic and vasodilator effects. Br J Pharmacol. 1989 Jun;97(2):409-18. doi: 10.1111/j.1476-5381.1989.tb11968.x. PMID: 2758224; PMCID: PMC1854538. 2. McKillop D, Pickup KJ. Different inhibition and induction profiles of hepatic drug metabolism in rats and dogs by two structurally related pyridyl diazinone cardiotonic agents. Biochem Pharmacol. 1991 Feb 1;41(3):411-7. doi: 10.1016/0006-2952(91)90538-g. PMID: 1994899.