KS15 | CAS#N/A | (cry) inhibitor| MedKoo

MedKoo Cat#: 565635 | Name: KS15

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KS15 is a novel cryptochrome (cry) inhibitor, enhancing e-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex.

Chemical Structure

KS15

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 565635

Name: KS15

CAS#: N/A

Chemical Formula: C20H22BrNO4

Exact Mass: 419.0732

Molecular Weight: 420.30

Elemental Analysis: C, 57.15; H, 5.28; Br, 19.01; N, 3.33; O, 15.23

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KS15; KS 15; KS-15

IUPAC/Chemical Name

(R,E)-3-(3-(1-(((4-Bromobenzyl)oxy)imino)ethyl)phenyl)-2-ethoxypropanoic acid

InChi Key

GWSVRVKPZVYTCS-VZMFNRANSA-N

InChi Code

InChI=1S/C20H22BrNO4/c1-3-25-19(20(23)24)12-16-5-4-6-17(11-16)14(2)22-26-13-15-7-9-18(21)10-8-15/h4-11,19H,3,12-13H2,1-2H3,(H,23,24)/b22-14+/t19-/m1/s1

SMILES Code

O=C(O)[C@H](OCC)CC1=CC=CC(/C(C)=N/OCC2=CC=C(Br)C=C2)=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 420.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jang J, Chung S, Choi Y, Lim HY, Son Y, Chun SK, Son GH, Kim K, Suh YG, Jung JW. The cryptochrome inhibitor KS15 enhances E-box-mediated transcription by disrupting the feedback action of a circadian transcription-repressor complex. Life Sci. 2018 May 1;200:49-55. doi: 10.1016/j.lfs.2018.03.022. Epub 2018 Mar 10. PubMed PMID: 29534992. 2: Zhu Z, Yang F, Chen P, Liu H, Cao W, Zhang K, Liu X, Zheng H. Emergence of novel Seneca Valley virus strains in China, 2017. Transbound Emerg Dis. 2017 Aug;64(4):1024-1029. doi: 10.1111/tbed.12662. Epub 2017 May 23. PubMed PMID: 28544501. 3: Chen Z, Yuan F, Li Y, Shang P, Schroeder R, Lechtenberg K, Henningson J, Hause B, Bai J, Rowland RRR, Clavijo A, Fang Y. Construction and characterization of a full-length cDNA infectious clone of emerging porcine Senecavirus A. Virology. 2016 Oct;497:111-124. doi: 10.1016/j.virol.2016.07.003. Epub 2016 Jul 25. PubMed PMID: 27459668. 4: Chun SK, Chung S, Kim HD, Lee JH, Jang J, Kim J, Kim D, Son GH, Oh YJ, Suh YG, Lee CS, Kim K. A synthetic cryptochrome inhibitor induces anti-proliferative effects and increases chemosensitivity in human breast cancer cells. Biochem Biophys Res Commun. 2015 Nov 13;467(2):441-6. doi: 10.1016/j.bbrc.2015.09.103. Epub 2015 Sep 25. PubMed PMID: 26407844.