Synonym
WJM-921; WJM921; WJM 921
IUPAC/Chemical Name
(R)-8-chloro-N-(5-chloropyridin-3-yl)-4-methyl-1,5-dioxo-2,3,4,5-tetrahydropyrrolo[1,2-a]quinazoline-3a(1H)-carboxamide
InChi Key
CSHDBBLSXAAVQZ-GOSISDBHSA-N
InChi Code
InChI=1S/C18H14Cl2N4O3/c1-23-16(26)13-3-2-10(19)7-14(13)24-15(25)4-5-18(23,24)17(27)22-12-6-11(20)8-21-9-12/h2-3,6-9H,4-5H2,1H3,(H,22,27)/t18-/m1/s1
SMILES Code
ClC1=CC(N(C(CC2)=O)[C@]2(C(NC3=CC(Cl)=CN=C3)=O)N(C)C4=O)=C4C=C1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
405.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
Ashton TD, Dans MG, Favuzza P, Ngo A, Lehane AM, Zhang X, Qiu D, Chandra Maity B, De N, Schindler KA, Yeo T, Park H, Uhlemann AC, Churchyard A, Baum J, Fidock DA, Jarman KE, Lowes KN, Baud D, Brand S, Jackson PF, Cowman AF, Sleebs BE. Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4. J Med Chem. 2023 Feb 22. doi: 10.1021/acs.jmedchem.2c02092. Epub ahead of print. PMID: 36812492.
