LSN-3213128 is a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor (enzyme IC50 values of <25 nM). LSN-3213128 is effective at Tumor Suppression in a Cancer Xenograft Model. Inhibition of AICARFT with compound LSN-3213128 results in dramatic elevation of 5-aminoimidazole 4-carboxamide ribonucleotide (ZMP) and growth inhibition in NCI-H460 and MDA-MB-231met2 cancer cell lines. Treatment with this inhibitor in a murine based xenograft model of triple negative breast cancer (TNBC) resulted in tumor growth inhibition.
MedKoo Cat#: 407848
Name: LSN-3213128
CAS#: 1941211-99-9 (free)
Chemical Formula: C17H16FN3O4S2
Exact Mass: 409.0566
Molecular Weight: 409.45
Elemental Analysis: C, 49.87; H, 3.94; F, 4.64; N, 10.26; O, 15.63; S, 15.66
The following data is based on the product molecular weight 409.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
