Synonym
Shield-1 Tosylate; Shield 1 Tosylate; Shield1 Tosylate; AquaShield-1; AquaShield 1; AquaShield1;
IUPAC/Chemical Name
(S)-(R)-3-(3,4-Dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl 1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate Tosylate
InChi Key
RGQLXMGMLXCQRQ-YQWFAZLASA-N
InChi Code
InChI=1S/C42H56N2O10.C7H8O3S/c1-7-33(31-27-38(49-4)40(51-6)39(28-31)50-5)41(45)44-18-9-8-13-34(44)42(46)54-35(16-14-29-15-17-36(47-2)37(25-29)48-3)30-11-10-12-32(26-30)53-24-21-43-19-22-52-23-20-43;1-6-2-4-7(5-3-6)11(8,9)10/h10-12,15,17,25-28,33-35H,7-9,13-14,16,18-24H2,1-6H3;2-5H,1H3,(H,8,9,10)/t33-,34+,35-;/m0./s1
SMILES Code
OS(=O)(C1=CC=C(C)C=C1)=O.O=C([C@@H]2N(C([C@H](C3=CC(OC)=C(OC)C(OC)=C3)CC)=O)CCCC2)O[C@H](C4=CC=CC(OCCN5CCOCC5)=C4)CCC6=CC=C(OC)C(OC)=C6
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
921.11
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Madsen D, Jørgensen FP, Palmer D, Roux ME, Olsen JV, Bols M, Schoffelen S,
Diness F, Meldal M. Design and Combinatorial Development of Shield-1 Peptide
Mimetics Binding to Destabilized FKBP12. ACS Comb Sci. 2020 Mar 9;22(3):156-164.
doi: 10.1021/acscombsci.9b00197. Epub 2020 Feb 23. PMID: 32027120.
2: Banaszynski LA, Chen LC, Maynard-Smith LA, Ooi AG, Wandless TJ. A rapid,
reversible, and tunable method to regulate protein function in living cells
using synthetic small molecules. Cell. 2006 Sep 8;126(5):995-1004. doi:
10.1016/j.cell.2006.07.025. PMID: 16959577; PMCID: PMC3290523.
3: Froschauer A, Kube L, Kegler A, Rieger C, Gutzeit HO. Tunable Protein
Stabilization In Vivo Mediated by Shield-1 in Transgenic Medaka. PLoS One. 2015
Jul 6;10(7):e0131252. doi: 10.1371/journal.pone.0131252. PMID: 26148066; PMCID:
PMC4493054.
4: Zmora O, Fleshner P, Barie PS, Segev L, Viola GM, Senagore AJ, Spinelli A,
Belotserkovsky O, Sharoni S, Emanuel N; SHIELD 1 Investigators. Effect of local
prolonged-release incisional doxycycline on surgical site infection prophylaxis
in abdominal colorectal surgery: the SHIELD 1 randomized clinical trial. Int J
Surg. 2024 Oct 1;110(10):6658-6666. doi: 10.1097/JS9.0000000000001824. PMID:
38869970; PMCID: PMC11486998.
5: Dogramaci M, Butt MA. The Influence of Slit Lamp Shield Size and Design in
Reducing Aerosol Transmission. Transl Vis Sci Technol. 2021 Nov 1;10(13):33.
doi: 10.1167/tvst.10.13.33. Erratum in: Transl Vis Sci Technol. 2022 Jan
3;11(1):21. doi: 10.1167/tvst.11.1.21. PMID: 34846521; PMCID: PMC8648061.
6: Khan MA, Ashraf G, Ashraf H, Francis IC, Wilcsek G. Efficacy of patient-sided
breath shields for slit-lamp examination. Can J Ophthalmol. 2023
Aug;58(4):369-374. doi: 10.1016/j.jcjo.2022.02.002. Epub 2022 Feb 27. PMID:
35231395.
7: Xu Y, Wang Y, Liang FS. Site-Specific m6 A Erasing via
Conditionally Stabilized CRISPR-Cas13b Editor. Angew Chem Int Ed Engl. 2023 Oct
23;62(43):e202309291. doi: 10.1002/anie.202309291. Epub 2023 Sep 15. PMID:
37713087; PMCID: PMC10592254.
8: Hong DP, Radke JB, White MW. Opposing Transcriptional Mechanisms Regulate
Toxoplasma Development. mSphere. 2017 Feb 22;2(1):e00347-16. doi:
10.1128/mSphere.00347-16. PMID: 28251183; PMCID: PMC5322347.
9: Mohamed NN, El-Anwar MW. New Metal Shield for the Endotracheal Tube during
Laser Endolaryngeal Surgery. Iran J Otorhinolaryngol. 2018 Sep;30(100):291-295.
PMID: 30245983; PMCID: PMC6147269.
10: Schoeber JP, van de Graaf SF, Lee KP, Wittgen HG, Hoenderop JG, Bindels RJ.
Conditional fast expression and function of multimeric TRPV5 channels using
Shield-1. Am J Physiol Renal Physiol. 2009 Jan;296(1):F204-11. doi:
10.1152/ajprenal.90473.2008. Epub 2008 Oct 8. PMID: 18842822.
