Abaperidone | CAS# 183849-43-6 | Antipsychotic

MedKoo Cat#: 571332 | Name: Abaperidone free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Abaperidone, also known as FI 8602, is an atypical antipsychotic. Reduced hsp70 in the prefrontal cortex may play a critical role in the etiology of many schizophrenia symptoms and may be linked to an atypical profile of antipsychotics, such as abaperidone.

Chemical Structure

Abaperidone free base

CAS#183849-43-6 (free base)

Theoretical Analysis

MedKoo Cat#: 571332

Name: Abaperidone free base

CAS#: 183849-43-6 (free base)

Chemical Formula: C25H25FN2O5

Exact Mass: 452.1748

Molecular Weight: 452.48

Elemental Analysis: C, 66.36; H, 5.57; F, 4.20; N, 6.19; O, 17.68

Price and Availability

Size	Price	Availability
1mg	USD 90.00	Ready to Ship
5mg	USD 250.00	Ready to Ship
10mg	USD 450.00	Ready to Ship
25mg	USD 750.00	Ready to Ship
50mg	USD 1,250.00	Ready to Ship
100mg	USD 2,250.00	Ready to Ship

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Related CAS #

183849-45-8 (HCl) 183849-43-6 (free base)

Synonym

Abaperidone; Abaperidone free base; FI 8602; FI-8602; FI8602;

IUPAC/Chemical Name

7-(3-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)propoxy)-3-(hydroxymethyl)-4H-1-benzopyran-4-one

InChi Key

ICAXEUYZCLRXKY-UHFFFAOYSA-N

InChi Code

InChI=1S/C25H25FN2O5/c26-18-2-4-20-23(12-18)33-27-24(20)16-6-9-28(10-7-16)8-1-11-31-19-3-5-21-22(13-19)32-15-17(14-29)25(21)30/h2-5,12-13,15-16,29H,1,6-11,14H2

SMILES Code

O=C1C(CO)=COC2=CC(OCCCN3CCC(C4=NOC5=C4C=CC(F)=C5)CC3)=CC=C12

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Certificate of Analysis

View CoA: current batch, Lot#Y22X12M03

QC Data

View QC data: current batch, Lot#Y22X12M03

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Biological target:

Abaperidone is a potent antagonist of 5-HT2A receptor and dopamine D2 receptor with IC50s of 6.2 and 17 nM.

In vitro activity:

TBD

In vivo activity:

Abaperidone, a novel drug with an atypical antipsychotic profile, was compared, at pharmacologically equivalent doses, with the atypical antipsychotics clozapine and risperidone and also with haloperidol, a classical antipsychotic. Abaperidone and clozapine reduced basal hsp70 mRNA expression in the rat striatum and in the prefrontal cortex. Reference: Prog Neuropsychopharmacol Biol Psychiatry. https://pubmed.ncbi.nlm.nih.gov/12551723/

Preparing Stock Solutions

The following data is based on the product molecular weight 452.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. García-Osta A, Frechilla D, Del Río J. Reduced basal and phencyclidine-induced expression of heat shock protein-70 in rat prefrontal cortex by the atypical antipsychotic abaperidone. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb;27(1):31-6. doi: 10.1016/s0278-5846(02)00311-1. PMID: 12551723.

In vitro protocol:

TBD

In vivo protocol:

1: García-Osta A, Frechilla D, Del Río J. Reduced basal and phencyclidine induced expression of heat shock protein-70 in rat prefrontal cortex by the atypical antipsychotic abaperidone. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb;27(1):31-6. PubMed PMID: 12551723. 2: Bolós J, Anglada L, Gubert S, Planas JM, Agut J, Príncep M, De la Fuente N, Sacristán A, Ortiz JA. 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). J Med Chem. 1998 Dec 31;41(27):5402-9. PubMed PMID: 9876110.