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MedKoo Cat#: 525991 | Name: Abaperidone HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Abaperidone, also known as FI 8602, is an antipsychotic. Reduced hsp70 in the prefrontal cortex may play a critical role in the etiology of many schizophrenia symptoms and may be linked to an atypical profile of antipsychotics, such as abaperidone.

Chemical Structure

Abaperidone HCl
Abaperidone HCl
CAS#183849-45-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 525991

Name: Abaperidone HCl

CAS#: 183849-45-8 (HCl)

Chemical Formula: C25H26ClFN2O5

Exact Mass: 0.0000

Molecular Weight: 488.94

Elemental Analysis: C, 61.41; H, 5.36; Cl, 7.25; F, 3.89; N, 5.73; O, 16.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
183849-45-8 (HCl) 183849-43-6 (free base)
Synonym
Abaperidone Hydrochloride; Abaperidone; Abaperidone HCl; FI 8602; FI-8602; FI8602;
IUPAC/Chemical Name
7-[3-[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]propoxy]-3-(hydroxymethyl)chromen-4-one hydrochloride
InChi Key
FUKIEXAUUAYHPB-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H25FN2O5.ClH/c26-18-2-4-20-23(12-18)33-27-24(20)16-6-9-28(10-7-16)8-1-11-31-19-3-5-21-22(13-19)32-15-17(14-29)25(21)30;/h2-5,12-13,15-16,29H,1,6-11,14H2;1H
SMILES Code
O=C1C(CO)=COC2=C1C=CC(OCCCN3CCC(C4=NOC5=CC(F)=CC=C45)CC3)=C2.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 488.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: García-Osta A, Frechilla D, Del Río J. Reduced basal and phencyclidine induced expression of heat shock protein-70 in rat prefrontal cortex by the atypical antipsychotic abaperidone. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Feb;27(1):31-6. PubMed PMID: 12551723. 2: Bolós J, Anglada L, Gubert S, Planas JM, Agut J, Príncep M, De la Fuente N, Sacristán A, Ortiz JA. 7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). J Med Chem. 1998 Dec 31;41(27):5402-9. PubMed PMID: 9876110.