Tylosin | Tylosin A | CAS#1401-69-0

MedKoo Cat#: 329835 | Name: Tylosin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tylosin, also known as Tylosin A, is an antibiotic and a bacteriostatic feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms. It is found naturally as a fermentation product of Streptomyces fradiae. It is a macrolide antibiotic. Tylosin is used in veterinary medicine to treat bacterial infections in a wide range of species and has a high margin of safety. It has also been used as a growth promotant in some species, and as a treatment for colitis in companion animals.

Chemical Structure

Tylosin

CAS#1401-69-0 (free base)

Theoretical Analysis

MedKoo Cat#: 329835

Name: Tylosin

CAS#: 1401-69-0 (free base)

Chemical Formula: C46H77NO17

Exact Mass: 915.5192

Molecular Weight: 916.11

Elemental Analysis: C, 60.31; H, 8.47; N, 1.53; O, 29.69

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 175.00
50mg	USD 350.00
100mg	USD 550.00

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Related CAS #

1401-69-0 (free base) 11032-12-5 (HCl) 11034-63-2 (lactate) 74610-55-2 (tatrate)

Synonym

Tylosin; Tylosin A; Fradizine; Tilosina; Tylan; Tylocine; Vubityl 200.

IUPAC/Chemical Name

2-((4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-(((2R,3R,4R,5S,6R)-5-(((2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-16-ethyl-4-hydroxy-15-((((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-5,9,13-trimethyl-2,10-dioxooxacyclohexadeca-11,13-dien-7-yl)acetaldehyde

InChi Key

WBPYTXDJUQJLPQ-VMXQISHHSA-N

InChi Code

InChI=1S/C46H77NO17/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3/b15-14+,23-18+/t24-,25+,26-,27-,28+,29+,30-,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45-,46-/m1/s1

SMILES Code

CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)\C=C\C(=C\[C@@H]1CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC)\C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 916.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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PMID: 39776687; PMCID: PMC11702248. 4: Klein U, Földi D, Nagy EZ, Tóth L, Belecz N, Költő K, Wehmann E, Marton S, Merenda M, Gastaldelli M, Catania S, Spergser J, Siesenop U, Vyt P, Bányai K, Kreizinger Z, Depondt W, Gyuranecz M. Antimicrobial susceptibility profiles of Mycoplasma hyosynoviae strains isolated from five European countries between 2018 and 2023. Sci Rep. 2025 Jan 7;15(1):1243. doi: 10.1038/s41598-024-85052-1. PMID: 39774192; PMCID: PMC11707295. 5: Wang Y, Zhao C, Zhao B, Duan X, Hao P, Liang X, Yang L, Gao Y. Transcriptome of Kurthia gibsonii TYL-A1 Revealed the Biotransformation Mechanism of Tylosin. Microorganisms. 2024 Dec 16;12(12):2597. doi: 10.3390/microorganisms12122597. PMID: 39770799; PMCID: PMC11676290. 6: Jafari Jozani R, Khallawi MFHA, Nguyen HTH, Mohammed MH, Petrovski K, Ren Y, Trott D, Hemmatzadeh F, Low WY. Phenotypic and Genotypic Analysis of Antimicrobial Resistance in Mycoplasma hyopneumoniae Isolated from Pigs with Enzootic Pneumonia in Australia. Pathogens. 2024 Nov 28;13(12):1044. doi: 10.3390/pathogens13121044. PMID: 39770304; PMCID: PMC11728671. 7: Fu J, Wu X, Zhang C, Tang Y, Zhou F, Zhang X, Fan S. Genomic Analysis of Talaromyces verruculosus SJ9: An Efficient Tetracycline-, Enrofloxacin-, and Tylosin-Degrading Fungus. Genes (Basel). 2024 Dec 21;15(12):1643. doi: 10.3390/genes15121643. PMID: 39766911; PMCID: PMC11675779. 8: Chen H, Wu X, Cui S, Li Y, Mu Y, Gao J, Liu H, Liu J. Residue Elimination Patterns and Determination of the Withdrawal Times of Seven Antibiotics in Eggs of Taihang Chickens. Animals (Basel). 2024 Dec 22;14(24):3701. doi: 10.3390/ani14243701. PMID: 39765605; PMCID: PMC11672755. 9: Fan Z, Lin Z, Zhai H, Cao Y, Wang H, Maiga A, Frejat FOA, Ren C, Wu CL. Design, Synthesis, and Activity Evaluation of C-23-Modified 5-O-Mycaminosyltylonolide Derivatives. ACS Med Chem Lett. 2024 Nov 25;15(12):2171-2180. doi: 10.1021/acsmedchemlett.4c00458. PMID: 39691534; PMCID: PMC11647724. 10: Stromer BS, Woodbury BL, Williams CF, Spiehs MJ. Combined Treatment Methods for Removal of Antibiotics from Beef Wastewater. ACS Omega. 2024 Nov 25;9(49):48721-48726. doi: 10.1021/acsomega.4c08114. PMID: 39676941; PMCID: PMC11635675. 11: Fang JR, Mu Y, Tang BB, Guo CH, Huang WB, Yong Q, Wang Z, Zhang JZ. [Spatial-temporal Distribution and Ecological Risk of Antibiotics in the Soils of a Typical Agricultural Watershed in the Three Gorges Reservoir Area]. Huan Jing Ke Xue. 2024 Nov 8;45(11):6583-6593. Chinese. doi: 10.13227/j.hjkx.202312064. PMID: 39628245. 12: Kursa O. Multidrug Resistance of Gallibacterium anatis Biovar Haemolytica Isolated from the Reproductive Tracts of Laying Hens. Pathogens. 2024 Nov 12;13(11):989. doi: 10.3390/pathogens13110989. PMID: 39599542; PMCID: PMC11597584. 13: Blondeau JM, Fitch SD. Comparison of the Minimum Inhibitory and Mutant Prevention Drug Concentrations for Pradofloxacin and 7 Other Antimicrobial Agents Tested Against Swine Isolates of Actinobacillus pleuropneumoniae and Pasteurella multocida. Molecules. 2024 Nov 19;29(22):5448. doi: 10.3390/molecules29225448. PMID: 39598838; PMCID: PMC11597606. 14: Salih HM, Amachawadi RG, Kang Q, Li Y, Nagaraja TG. In-Vitro Antimicrobial Activities of Grape Seed, Green Tea, and Rosemary Phenolic Extracts Against Liver Abscess Causing Bacterial Pathogens in Cattle. Microorganisms. 2024 Nov 11;12(11):2291. doi: 10.3390/microorganisms12112291. PMID: 39597680; PMCID: PMC11596820. 15: Park JH, Bae KS, Kang J, Park ER, Yoon JK. Comprehensive Study of Antibiotic Resistance in Enterococcus spp.: Comparison of Influents and Effluents of Wastewater Treatment Plants. Antibiotics (Basel). 2024 Nov 11;13(11):1072. doi: 10.3390/antibiotics13111072. PMID: 39596765; PMCID: PMC11590936. 16: Iancu I, Igna V, Popa SA, Imre K, Pascu C, Costinar L, Degi J, Gligor A, Iorgoni V, Badea C, Nichita I, Herman V. Etiology and antimicrobial resistance of subclinical mastitis pathogens Staphylococcus aureus, Streptococcus spp. and Enterococcus spp. in sheep milk. Vet Res Commun. 2024 Nov 22;49(1):30. doi: 10.1007/s11259-024-10579-7. PMID: 39576396. 17: Barshevskaya LV, Sotnikov DV, Zvereva EA, Dzantiev BB, Zherdev AV. Comparative Characteristics of Immunochromatographic Test Systems for Tylosin Antibiotic in Meat Products. Sensors (Basel). 2024 Oct 25;24(21):6865. doi: 10.3390/s24216865. PMID: 39517762; PMCID: PMC11548405. 18: Phatinuwat K, Atichartpongkul S, Jumpathong W, Mongkolsuk S, Fuangthong M. 16S rRNA methyltransferase KsgA contributes to oxidative stress and antibiotic resistance in Pseudomonas aeruginosa. Sci Rep. 2024 Nov 3;14(1):26484. doi: 10.1038/s41598-024-78296-4. PMID: 39489773; PMCID: PMC11532479. 19: Wang CH, Chung KT, Su LY, Wu WJ, Wang PH, Lee MC, Shen SC, Wu CH. Chinese Herbal Medicines as Natural Alternative Products to Antibiotics in Weaned Piglets through Intestinal Microbiota Regulation. Int J Mol Sci. 2024 Oct 14;25(20):11034. doi: 10.3390/ijms252011034. PMID: 39456815; PMCID: PMC11506844. 20: Huang J, Zhang Y, Lin Y, Chen W, Yi J, Li X, Gao C, Wu F, Huang Z, Gao H, Guo B. Development and evaluation of novel taste-masking tilmicosin microcapsules containing octenylsuccinic anhydride modified starch and maltodextrin as wall materials. Int J Biol Macromol. 2024 Dec;282(Pt 1):136619. doi: 10.1016/j.ijbiomac.2024.136619. Epub 2024 Oct 16. PMID: 39419137.