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MedKoo Cat#: 571278 | Name: A1777

Description:

WARNING: This product is for research use only, not for human or veterinary use.

A1777 is a selective 5-lipoxygenase inhibitor that reduces leukocytes proliferation without affecting the eosinophils of mast cells.

Chemical Structure

A1777
A1777
CAS#90316-11-3

Theoretical Analysis

MedKoo Cat#: 571278

Name: A1777

CAS#: 90316-11-3

Chemical Formula: C21H24O4

Exact Mass: 340.1675

Molecular Weight: 340.42

Elemental Analysis: C, 74.09; H, 7.11; O, 18.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AA1777; AA-1777; AA 1777
IUPAC/Chemical Name
2,7-Dodecadiynoic acid, 12-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-
InChi Key
SOXDIYGAYKFKPK-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H24O4/c1-15-16(2)21(25)18(17(3)20(15)24)13-11-9-7-5-4-6-8-10-12-14-19(22)23/h6-11,13H2,1-3H3,(H,22,23)
SMILES Code
O=C(O)C#CCCCC#CCCCCC1=C(C)C(C(C)=C(C)C1=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 340.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tanaka K, Ueno A, Katori M. Roles of leukotrienes in two rat allergic inflammatory models; IgE-mediated and IgG-antigen complex-induced pleurisies. Prostaglandins. 1986 Jun;31(6):1099-116. PubMed PMID: 3020615. 2: Qian J, Steigerwald K, Combs KA, Barton MC, Groden J. Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis. Oncogene. 2007 Jul 19;26(33):4872-6. Epub 2007 Feb 5. PubMed PMID: 17297457. 3: Nagai K, Katori M. Possible changes in the leukocyte membrane as a mechanism of leukocyte adhesion to the venular walls induced by leukotriene B4 and fMLP in the microvasculature of the hamster cheek pouch. Int J Microcirc Clin Exp. 1988 Nov;7(4):305-14. PubMed PMID: 2851564.