MedKoo Cat#: 561344 | Name: NPD9948

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NPD9948 is a competitive MTH1 inhibitor.

Chemical Structure

NPD9948
NPD9948
CAS#59856-85-8

Theoretical Analysis

MedKoo Cat#: 561344

Name: NPD9948

CAS#: 59856-85-8

Chemical Formula: C13H14N6

Exact Mass: 254.1280

Molecular Weight: 254.30

Elemental Analysis: C, 61.40; H, 5.55; N, 33.05

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Related CAS #
No Data
Synonym
NPD9948; NPD-9948; NPD 9948;
IUPAC/Chemical Name
N6-Phenethyl-9H-purine-2,6-diamine
InChi Key
VVAAYEZVIGGGED-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H14N6/c14-13-18-11(10-12(19-13)17-8-16-10)15-7-6-9-4-2-1-3-5-9/h1-5,8H,6-7H2,(H4,14,15,16,17,18,19)
SMILES Code
NC1=NC(NCCC2=CC=CC=C2)=C3N=CNC3=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
NPD9948 is a competitive MTH1 inhibitor.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 254.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H. Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival. Sci Rep. 2016 May 23;6:26521. doi: 10.1038/srep26521. PubMed PMID: 27210421; PubMed Central PMCID: PMC4876372.