MedKoo Cat#: 525181 | Name: GSK 894281

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK 894281 is a ghrelin receptor agonist. It is a compound that produces myocardial degeneration/necrosis in rats after 28 days at doses of 0.3, 1, 10, or 60 mg/kg/d.

Chemical Structure

GSK 894281
GSK 894281
CAS#874958-63-1

Theoretical Analysis

MedKoo Cat#: 525181

Name: GSK 894281

CAS#: 874958-63-1

Chemical Formula: C24H28FN3O4S

Exact Mass: 473.1785

Molecular Weight: 473.56

Elemental Analysis: C, 60.87; H, 5.96; F, 4.01; N, 8.87; O, 13.51; S, 6.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GSK 894281; GSK-894281; GSK894281.
IUPAC/Chemical Name
Benzenesulfonamide, N-(5-((3R,5S)-3,5-dimethyl-1-piperazinyl)-2-methoxyphenyl)-3-fluoro-4-(5-methyl-2-furanyl)-, rel-
InChi Key
OIWVNMRPHUCLHN-IYBDPMFKSA-N
InChi Code
InChI=1S/C24H28FN3O4S/c1-15-13-28(14-16(2)26-15)18-6-10-24(31-4)22(11-18)27-33(29,30)19-7-8-20(21(25)12-19)23-9-5-17(3)32-23/h5-12,15-16,26-27H,13-14H2,1-4H3/t15-,16+
SMILES Code
c1(cc(c(cc1)c1oc(cc1)C)F)S(=O)(=O)Nc1c(ccc(c1)N1C[C@H](N[C@H](C1)C)C)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 473.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Stokes AH, Falls JG, Yoon L, Cariello N, Faiola B, Colton HM, Jordan HL, Berridge BR. Integrated approach to early detection of cardiovascular toxicity induced by a ghrelin receptor agonist. Int J Toxicol. 2015 Mar-Apr;34(2):151-61. doi: 10.1177/1091581815573029. Epub 2015 Feb 26. PubMed PMID: 25722321. 2: Shafton AD, Sanger GJ, Witherington J, Brown JD, Muir A, Butler S, Abberley L, Shimizu Y, Furness JB. Oral administration of a centrally acting ghrelin receptor agonist to conscious rats triggers defecation. Neurogastroenterol Motil. 2009 Jan;21(1):71-7. doi: 10.1111/j.1365-2982.2008.01176.x. Epub 2008 Aug 6. PubMed PMID: 18694442.