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MedKoo Cat#: 532293 | Name: MRS2690

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MRS2690 is a potent P2Y14 receptor agonist (EC50 = 49 nM) that displays 7-fold higher potency than UDP-glucose.

Chemical Structure

MRS2690
MRS2690
CAS#7077-89-6

Theoretical Analysis

MedKoo Cat#: 532293

Name: MRS2690

CAS#: 7077-89-6

Chemical Formula: C15H22N2Na2O16P2S

Exact Mass: 625.9961

Molecular Weight: 626.33

Elemental Analysis: C, 28.77; H, 3.54; N, 4.47; Na, 7.34; O, 40.87; P, 9.89; S, 5.12

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
MRS2690; MRS 2690; MRS-2690.
IUPAC/Chemical Name
sodium (2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl [({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}(sodiooxy)phosphoryl)oxy]phosphonate
InChi Key
TYVFMVSNSGMZPA-QBNUFUENSA-L
InChi Code
InChI=1S/C15H24N2O16P2S.2Na/c18-3-5-8(20)10(22)12(24)14(31-5)32-35(27,28)33-34(25,26)29-4-6-9(21)11(23)13(30-6)17-2-1-7(19)16-15(17)36;;/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,25,26)(H,27,28)(H,16,19,36);;/q;2*+1/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14-;;/m1../s1
SMILES Code
O=P(OP(O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)([O-])=O)(OC[C@H]2O[C@@H](N(C(N3)=S)C=CC3=O)[C@H](O)[C@@H]2O)O[Na].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 626.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Alsaqati M, Latif ML, Chan SL, Ralevic V. Novel vasocontractile role of the P2Y₁₄ receptor: characterization of its signalling in porcine isolated pancreatic arteries. Br J Pharmacol. 2014 Feb;171(3):701-13. doi: 10.1111/bph.12473. PubMed PMID: 24138077; PubMed Central PMCID: PMC3969082. 2: Gao ZG, Wei Q, Jayasekara MP, Jacobson KA. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2013 Mar;9(1):31-40. doi: 10.1007/s11302-012-9325-4. Epub 2012 Jul 24. PubMed PMID: 22825617; PubMed Central PMCID: PMC3568423. 3: Gao ZG, Ding Y, Jacobson KA. UDP-glucose acting at P2Y14 receptors is a mediator of mast cell degranulation. Biochem Pharmacol. 2010 Mar 15;79(6):873-9. doi: 10.1016/j.bcp.2009.10.024. Epub 2009 Nov 5. PubMed PMID: 19896471; PubMed Central PMCID: PMC2812605.

View History

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