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MedKoo Cat#: 329625 | Name: Ritipenem Acoxil

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ritipenem Acoxil, also known as RIPM-AC, is an antibiotics. RIPM-AC showed clinical efficacy similar to those of CTM-HE and posed no particular safety problems. It is expected to be a useful antibiotic for the treatment of bacterial pneumonia.

Chemical Structure

Ritipenem Acoxil
Ritipenem Acoxil
CAS#99376-22-4

Theoretical Analysis

MedKoo Cat#: 329625

Name: Ritipenem Acoxil

CAS#: 99376-22-4

Chemical Formula: C13H16N2O8S

Exact Mass: 360.0627

Molecular Weight: 360.34

Elemental Analysis: C, 43.33; H, 4.48; N, 7.77; O, 35.52; S, 8.90

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
99376-22-4 87238-52-6
Synonym
Ritipenem Acoxil; RIPM-AC; Ritipenem acetoxymethyl ester.
IUPAC/Chemical Name
4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-6-(1-hydroxyethyl)-7-oxo-, (acetyloxy)methyl ester, (5R-(5-alpha,6-beta(R*)))-
InChi Key
FZKGLCPKPZBGLX-ZDRUMUKXSA-N
InChi Code
InChI=1S/C13H16N2O8S/c1-5(16)8-10(18)15-9(12(19)23-4-22-6(2)17)7(24-11(8)15)3-21-13(14)20/h5,8,11,16H,3-4H2,1-2H3,(H2,14,20)/t5-,8-,11-/m1/s1
SMILES Code
O=C(C(N12)=C(COC(N)=O)S[C@]2([H])[C@H]([C@H](O)C)C1=O)OCOC(C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 360.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Saito A, Sakamoto M, Saito A, Ohmichi M, Hiraga Y, Kikuchi K, Ohsaki Y, Sasaki N, Matsumoto H, Suda T, Tsuzino M, Hirai Y, Inoue H, Yoshida M, Mouri T, Kobayashi H, Chiba S, Ito T, Moriya K, Bando T, Takeuchi K, Tanifuji Y, Shirato K, Tanno Y, Nakashima M, et al. [A comparative study on the efficacies of ritipenem acoxil and cefotiam hexetil in bacterial pneumonia by the double-blind method]. Jpn J Antibiot. 1996 Feb;49(2):144-74. Japanese. PubMed PMID: 8721077. 2: Poggesi I, Spinelli R, Frigerio E, Strolin Benedetti M, Carra L, Sassella D, Rimoldi R. A study of the pharmacokinetics and tolerability of ritipenem acoxil in healthy volunteers following multiple oral dosing. J Antimicrob Chemother. 1997 Aug;40(2):291-4. PubMed PMID: 9301999. 3: Saito A, Saito A, Kawakami Y, Yamaguchi E, Koba H, Abe S, Ohmichi M, Hiraga Y, Kikuchi K, Ohsaki Y, Matsumoto H, Inoue H, Yoshida M, Mouri T, Kobayashi H, Ito T, Bando T, Takeuchi K, Hirano H, Tanifuji Y, Tanno Y, Shirato K, Takahashi M, Sakamoto M, Nakashima M, et al. [Comparative study on the efficacy of ritipenem acoxil and cefotiam hexetil in chronic lower respiratory tract infections by the double-blind method]. Jpn J Antibiot. 1996 Mar;49(3):219-49. Japanese. PubMed PMID: 8935119. 4: Interpretation of the bacteriologic outcome of antibiotic treatment for uncomplicated cystitis: impact of the definition of significant bacteriuria in a comparison of ritipenem acoxil with norfloxacin. Swedish Urinary Tract Infection Study Group. Clin Infect Dis. 1995 Mar;20(3):507-13. PubMed PMID: 7756468. 5: Boersma WG, Puister SM, van Altena R, de Vries-Hospers HG, Molinari M, Koëter GH. Clinical and bacteriological efficacy and tolerability of FCE 22891 in patients with exacerbations of chronic obstructive pulmonary disease. Antimicrob Agents Chemother. 1994 Apr;38(4):872-5. PubMed PMID: 8031062; PubMed Central PMCID: PMC284559.