Norverapamil HCl | CAS# 67812-42-4 (HCl) | Ca2+ channel blocker

MedKoo Cat#: 561316 | Name: Norverapamil HCl

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Norverapamil HCl is a calcium channel blocker. It is the main active metabolite of verapamil.

Chemical Structure

Norverapamil HCl

CAS#67812-42-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 561316

Name: Norverapamil HCl

CAS#: 67812-42-4 (HCl)

Chemical Formula: C26H37ClN2O4

Exact Mass: 0.0000

Molecular Weight: 477.04

Elemental Analysis: C, 65.46; H, 7.82; Cl, 7.43; N, 5.87; O, 13.42

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 350.00	2 weeks
10mg	USD 650.00	2 weeks

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Related CAS #

67018-85-3 (free base) 67812-42-4 (HCl)

Synonym

Norverapamil hydrochloride; Norverapamil HCl;

IUPAC/Chemical Name

2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethylamino]-2-propan-2-ylpentanenitrile hydrochloride

InChi Key

OEAFTRIDBHSJDC-UHFFFAOYSA-N

InChi Code

InChI=1S/C26H36N2O4.ClH/c1-19(2)26(18-27,21-9-11-23(30-4)25(17-21)32-6)13-7-14-28-15-12-20-8-10-22(29-3)24(16-20)31-5;/h8-11,16-17,19,28H,7,12-15H2,1-6H3;1H

SMILES Code

N#CC(C(C)C)(C1=CC=C(OC)C(OC)=C1)CCCNCCC2=CC=C(OC)C(OC)=C2.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	15.0	31.44
	DMSO	20.5	42.97
	Ethanol	10.0	20.96
	PBS (pH 7.2)	0.3	0.52
	Water	50.0	104.81

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 477.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Fried K, Wainer IW. Column-switching techniques in the biomedical analysis of stereoisomeric drugs: why, how and when. J Chromatogr B Biomed Sci Appl. 1997 Feb 7;689(1):91-104. Review. PubMed PMID: 9061485. 2: Anderson P. Pharmacokinetics of calcium channel blocking agents. Acta Pharmacol Toxicol (Copenh). 1986;58 Suppl 2:43-57. Review. PubMed PMID: 2940799. 3: Hamann SR, Blouin RA, McAllister RG Jr. Clinical pharmacokinetics of verapamil. Clin Pharmacokinet. 1984 Jan-Feb;9(1):26-41. Review. PubMed PMID: 6362951. 4: Kates RE. Calcium antagonists. Pharmacokinetic properties. Drugs. 1983 Feb;25(2):113-24. Review. PubMed PMID: 6339196.