Nortensin | CAS# 58934-32-0 | antihypertensive drug

MedKoo Cat#: 414486 | Name: Nortensin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nortensin is an antihypertensive drug consisting of furosemide & reserpine.

Chemical Structure

Nortensin

CAS#58934-32-0

Theoretical Analysis

MedKoo Cat#: 414486

Name: Nortensin

CAS#: 58934-32-0

Chemical Formula: C45H51ClN4O14S

Exact Mass: 938.2811

Molecular Weight: 939.43

Elemental Analysis: C, 57.53; H, 5.47; Cl, 3.77; N, 5.96; O, 23.84; S, 3.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Nortensin

IUPAC/Chemical Name

methyl (1S,2R,4aS,13bR,14aS)-2,11-dimethoxy-3-((3,4,5-trimethoxybenzoyl)oxy)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate 4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoate

InChi Key

BXNCBSRKUNHOJE-PTTJSDRVSA-N

InChi Code

InChI=1S/C33H40N2O9.C12H11ClN2O5S/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19;13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3;1-5,15H,6H2,(H,16,17)(H2,14,18,19)/t18-,22+,24-,27?,28+,31+;/m1./s1

SMILES Code

CO[C@H]1C(OC(c2cc(OC)c(OC)c(OC)c2)=O)C[C@@H]3CN4CCc(c([C@H]4C[C@@H]3[C@@H]1C(OC)=O)[nH]5)c6c5cc(OC)cc6.NS(=O)(c7c(Cl)cc(NCc8ccco8)c(C(O)=O)c7)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 939.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Klenke L, Büchel CG. Weiterführende Bluthochdruckbehandlung mit Nortensin [Continued treatment of hypertension with Nortensin]. Z Allgemeinmed. 1973 Feb 20;49(5):231-4. German. PMID: 4713072. 2: Hirsch W. Zur Therapie des Symptoms Hypertonie mit Nortensin [Therapy of the hypertensive symptom using Nortensin]. Ther Ggw. 1971 Jul;110(7):999-1002 passim. German. PMID: 5564616. 3: Carl G. Hochdruckbehandlung bei Stoffwechselgesunden und Diabetikern. Die galenisch neuartigen Furosemid-Reserpin-Kombinationen Nortensin Kapseln und Nortensin mite Kapseln [Management of hypertension in subjects with healthy metabolism and in diabetics. The new galenian furosemide-reserpine combinations Nortensin capsules and Nortensin mite capsules]. ZFA (Stuttgart). 1979 May 10;55(13):835-8. German. PMID: 452653. 4: Franck H, Gruhl M. Therapeutische Erfahrungen mit Nortensin bei der Behandlung des Schwangerschaftshochdrucks [Therapeutic experiences with Nortensin in the therapy of hypertension due to pregnancy]. MMW Munch Med Wochenschr. 1974 Mar 8;116(10):521-4. German. PMID: 4206421. 5: Moll HC. Saluresetherapie der Hypertonie. Erfahrungen mit Furosemid-Reserpin (Nortensin) [Saluretic treatment of hypertension. Experiences with furosemide- reserpine (Nortensin)]. Munch Med Wochenschr. 1971 Jun 25;113(26):987-90. German. PMID: 5108974.